| 海马中5-羟色胺对慢波睡眠的影响 |
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| 引用本文： | 李春华,张瑾,赵乐章,朱国庆,钟明奎,桂丽,张景行. 海马中5-羟色胺对慢波睡眠的影响[J]. 中国中医基础医学杂志, 2006, 12(11): 844-845 |
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| 作者姓名： | 李春华 张瑾 赵乐章 朱国庆 钟明奎 桂丽 张景行 |
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| 作者单位： | 1. 安徽医科大学,睡眠研究室和生理教研室,安徽,合肥,230032
2. 南京医科大学,生理系,江苏,南京,210029 |
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| 基金项目： | 安徽医科大学校科研和教改项目 |
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| 摘 要： | 目的:研究海马中5-羟色胺(5-HT)对大鼠慢波睡眠的影响。方法:采用脑立体定位、核团微量注射和多导睡眠描记技术。结果:5-HT前体5-羟色胺酸(5-HTP)引起慢波睡眠(SWS)和总睡眠时间(TST)增多,觉醒(W)减少;非特异性5-HT受体阻断剂麦角新碱(MS)对睡眠无直接影响,但可完全阻断5-HTP的促睡眠效应。结论:海马中5-HT具有促睡眠效应。
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| 关 键 词： | 5-羟色胺 睡眠 海马 |
| 文章编号： | 1006-3250（2006）11-0844-02 |
| 收稿时间： | 2006-03-14 |
| 修稿时间： | 2006-03-14 |
Effect of Serotonin in the Hippocampus on Slow Wave Sleep |
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| LI Chun-hua,ZHANG Jin,ZHAO Yue-zhang,ZHU Guo-qing,ZHONG Ming-kui,GUI Li,ZHANG Jin-xing. Effect of Serotonin in the Hippocampus on Slow Wave Sleep[J]. Chinese Journal of Basic Medicine In Traditional Chinese Medicine, 2006, 12(11): 844-845 |
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| Authors: | LI Chun-hua ZHANG Jin ZHAO Yue-zhang ZHU Guo-qing ZHONG Ming-kui GUI Li ZHANG Jin-xing |
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| Affiliation: | 1. Department of Physiology, Anhui Medical University, Hefei 230032, China ; 2. Departmentt of Physiology, Nanjing Medical University, Nanjing 210029, China |
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| Abstract: | Objective: To study serotonin(5-HT) in the hippocampus on sleep.Methods: Stereotaxic surgery,microinjection and polysomnography(PSG).Results: Microinjection of 5-hydroxytryptaphan(5-HTP),the immediate precursor of 5-HT, into the hippocampus,enhanced slow wave sleep(SWS)and total sleep time(TST), but decreased W.Microinjection of methlysergide(MS),an antagonist of 5-HT receptor,into the hippocampus,had no direct effect on sleep,but abolished the SWS-promoting effect of 5-HTP completely.Conclusion: 5-HT promotes SWS in the hippocampus. |
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| Keywords: | 5-HT sleep hippocampus |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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