Mouse hypothalamic GT1-7 cells demonstrate AMPK-dependent intrinsic glucose-sensing behaviour |
| |
| Authors: | C. Beall D. L. Hamilton J. Gallagher L. Logie K. Wright M. P. Soutar S. Dadak F. B. Ashford E. Haythorne Q. Du A. Jovanovi? R. J. McCrimmon M. L. J. Ashford |
| |
| Affiliation: | Medical Research Institute, Division of Cardiovascular & Diabetes Medicine, Ninewells Hospital & Medical School, University of Dundee, Dundee, DD1 9SY, UK. |
| |
| Abstract: | Aims/hypothesis Hypothalamic glucose-excited (GE) neurons contribute to whole-body glucose homeostasis and participate in the detection of hypoglycaemia. This system appears defective in type 1 diabetes, in which hypoglycaemia commonly occurs. Unfortunately, it is at present unclear which molecular components required for glucose sensing are produced in individual neurons and how these are functionally linked. We used the GT1-7 mouse hypothalamic cell line to address these issues. |
| |
| Keywords: | |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
|
