| 半夏泻心汤对小鼠胃排空的影响 |
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| 引用本文： | 张胜,吴春福,车轶.半夏泻心汤对小鼠胃排空的影响[J].中药药理与临床,2000,16(1):1-3. |
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| 作者姓名： | 张胜 吴春福 车轶 |
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| 作者单位： | [1]沈阳药科大学中药药理教研室 [2]辽宁省医药工业研究院，沈阳110015 |
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| 基金项目： | 辽宁省自然科学基金! 51 90 2 2 |
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| 摘 要： | 半夏泻心汤对正常小鼠胃排空无影响，能拮抗阿托品、芬氟拉明、多巴胺所致的小鼠胃排空抑制，但对左旋麻黄碱和吗啡所致抑制无拮抗作用，同时对新斯的明和胃复安引起的小鼠胃排空亢进有拮抗作用。提示本方对偏抑或偏亢机能状态下的胃排空具有双向调节作用，其作用机制可能与胆碱受体、多巴胺受体及5－羟色胺受体系统有关。
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| 关 键 词： | 半夏泻心汤 胃排空 阿托品 芬氟拉明 多巴胺 吗啡 左旋麻黄碱 胃复安 新斯的明 胃动力障碍 |
Effect of Banxiaxiexin tang on Gastric Emptying in Mice |
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| Zhang Sheng,Wu Chunfu,Che Yi,Chen Duo.Effect of Banxiaxiexin tang on Gastric Emptying in Mice[J].Pharmacology and Clinics of Chinese Materia Medica,2000,16(1):1-3. |
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| Authors: | Zhang Sheng Wu Chunfu Che Yi Chen Duo |
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| Abstract: | Banxiaxiexin-tang is an ancient recipe composed by Zhang Zhongjing two thousand years ago. It is used, clinically,for treatment of gastrointestinal disorders. The present study reported its gastric prokinetic effect in mice. The results showed that this recipe did not affect the gastric emptying in normal mice. However, it significantly antagonized the delayed gastric emptying induced by atropine, dl fenfluramine and dopamine, respectively. It showed no significant effect on ephedrine and morphine induced gastric emptying inhibition. The recipe also antagonized neostigmine induced gastric emptying stimulation in mice. These result ssuggest that Banxiaxiexin tang have dual directional regulating effect on gastric emptying via a mechanism of action mainly on cholinergic, dopaminergic and serotonergic systems. |
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| Keywords: | Banxiaxiexin tang gastric emptying atropine dl fenfluramine dopamine morphine ephedrine neostigmine |
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