男性不育症患者血清TNF-α、T、FSH、PRL检测的临床意义

目的：探讨男性不育症患者血清TNF-α、T、FSH、PRL水平的变化及临床意义。方法：应用放射免疫分析对36例男性不育症患者进行了血清TNF-α、T、FSH、PRL检测,并与35例男性正常人作比较。结果：男性不育症患者血清T水平非常显著地低于男性正常人组（P〈0.01）,而TNFα-、FSH、PRL水平又非常显著地高于男性正常人组（P〈0.01）,血清TNF-α水平与T水平呈负相关（r=-0.5184,P〈0.01）,与FSH、PRL水平呈正相关（r=0.6184、0.5925,P〈0.01）。结论：检测男性不育症患者血清TNF-α、T、FSH、PRL水平的变化对诊断、预后判断及治疗均有较大的临床价值。

Clinical Significance of Measurement of Serum TNF-α, T, FSH and PRL Levels in Male Infertility

Objective To explore the significance of changes of serum TNF-α,T,FSH and PRL levels in male patients with infertility.Methods Serum TNF-α,T,FSH and PRL(with RIA) were measured in 36 male patients with infertility and 35 male controls.Results Serum T level was significantly lower in the patients than those in controls(P<0.01),while the serum TNF-α,FSH and PRL levels were significantly higher in the patients(P<0.01).Serum TNF-α level was negatively correlated with T level in the patients(r=-0.5184,P<0.01) and positively correlated with FSH,PRL levels(r=0.6184,0.5925,P<0.01).Conclusion Serum TNF-α,T,FSH and PRL levels were significantly changed in male with infertility and determination of which might useful for prognosis and treatment clinically.