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The Role of Lymph Node Metastasis in the Systemic Dissemination of Breast Cancer |
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| Authors: | S. David Nathanson MD David Kwon MD Alissa Kapke MS Sharon Hensley Alford MPH PhD Dhananjay Chitale MD |
| Affiliation: | (1) Department of Surgery, Henry Ford Health System, Detroit, MI, USA;(2) Department of Biostatistics and Research Epidemiology, Henry Ford Health System, Detroit, MI, USA;(3) Department of Pathology, Henry Ford Health System, Detroit, MI, USA |
| Abstract: | BackgroundLymphatic invasion is necessary for regional lymph node (RLN) metastasis in breast cancer (BC), while systemic metastasis requires blood vessel (BV) invasion. The site of BV invasion could be at the primary BC site or through lymphovascular anastomoses. The vague pathologic term “lymphovascular invasion” (LVI) encourages the belief that peri/intratumoral BV invasion may be common. We investigated the relative contribution of RLN metastasis to systemic metastasis by studying the relationship among LVI and RLN and/or systemic metastasis in a population-based cohort of breast cancer patients. |
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