NLR、MPV及hs-CRP与冠心病的临床类型及冠脉狭窄程度的关联

目的:监测中性粒细胞/淋巴细胞(NLR)、平均血小板体积（MPV）及超敏C反应蛋白（hs-CRP）3项指标在冠心病类型及冠脉狭窄程度中的临床价值。方法: 选取我院心内科行冠脉造影明确为冠心病的220例患者，其中不稳定型心绞痛(UAP)64例，急性心肌梗死(AMI)76例，对照组为稳定型心绞痛（SAP）患者80例。分别监测两组患者的白细胞计数（WBC）,中性粒细胞计数（NC）,淋巴细胞计数（LC）,hs-CRP,血小板计数（PLC）,MPV,计算NLR，分析冠心病类型及冠脉狭窄程度与3项指标的关联性。并进行多因素Logistic回归分析。结果: WBC、NLR、MPV、hs-CRP在3组的差异有统计学意义（P<0.05），不同程度的冠脉狭窄中三者亦有统计学差异，冠脉狭窄愈严重，NLR、hs-CRP及MPV愈大（P<0.05或P<0.01）。多因素回归分析提示hs-CRP是UAP及AMI的危险因素，NLR和MPV是AMI的独立危险因素。结论: NLR、MPV、hs-CRP与冠心病临床类型及冠脉狭窄程度有关联。

Neutrophil/lymphocyte ratio,mean platelet volume and high-sensitivity C-reactive protein are associated with types of coronary heart disease and degrees of coronary artery stenosis

AIM:To study the clinical value of neutrophil/lymphocyte ratio (NLR), mean platelet volume (MPV) and high-sensitivity C-reactive protein (hs-CRP) for the types of coronary heart disease and the degrees of coronary artery stenosis. METHODS: Two hundred and twenty patients diagnosed with coronary heart disease based on coronary angiography were selected for the study. Among them, 64 unstable angina (UAP) patients and 76 acute myocardial infarction (AMI) patients were in the experimental group, and 80 stable angina patients were in the control group. White blood cell count, neutrophil count, lymphocyte count, hs-CRP, platelet count and MPV of the two groups were recorded and NLR was calculated. The association among the three indexes (NLR, MPV and hs-CRP) and types of coronary heart disease and degrees of coronary artery stenosis was analyzed. Logistic regression was conducted to probe the diagnostic and prognostic significance of the three indexes. RESULTS: Statistically significant differences were found in NLR, MPV and hs-CRP between experiment group and control group, between unstable angina and acute myocardial infarction, and between degrees of coronary artery stenosis. NLR was found to be a significant factor in predicting the heart function classifications and the all-cause re-hospitalization rates. CONCLUSION: NLR, MPV and hs-CRP have some clinical value for types of coronary heart disease and degrees of coronary artery stenosis, as well as for the prognosis of postoperative PCI patients.