"Two" much of a good thing: telomere damage-induced genome doubling drives tumorigenesis |
| |
Authors: | Varetti Gianluca Pellman David |
| |
Institution: | Department of Pediatric Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02115, USA. |
| |
Abstract: | Data from human tumors and mouse models suggest that tetraploidy, one example of polyploidy, can promote tumorigenesis. In this issue of Cancer Cell, Davoli and De Lange make important connections between tetraploidy, tumorigenesis, and telomere crisis-a common event during the development of human cancers. |
| |
Keywords: | |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|