Papillary glioneuronal tumour: clinicopathological and biochemical study of one case with 7-year follow up |
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Authors: | C Bouvier-Labit L Daniel H Dufour F Grisoli D Figarella-Branger |
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Institution: | Service d’Anatomie Pathologique et de Neuropathologie, H?pital de la Timone, chemin de l’Armée d’Afrique, F-13385 Marseilles cedex 05, France e-mail: dfigarel@ap-hm.fr, Tel.: +33-4-91-324588, Fax: +33-4-91-254232, FR Service de Neurochirurgie, H?pital de la Timone, chemin de l’Armée d’Afrique, F-13385 Marseilles cedex 05, France, FR
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Abstract: | Among the mixed glioneuronal tumours, a new variant called papillary glioneuronal tumour has recently been delineated. A
case occurring in a 23-year-old man is reported. The tumour was cystic with a mural nodule enhanced by gadolinium injection.
It was located within the left parieto-occipital lobe. Surgical excision showed a greyish friable tumour with cystic areas.
Histopathological examination revealed a pseudopapillary component comprising a single layer of regular cells, arranged around
hyalinised vessels. These cells were immunoreactive with anti-glial fibrillary acidic protein and HNK1 antibodies. A neurocytoma-like
component coexisted with round blind cells and focal fibrillary rosettes. These cells were immunostained by anti-neuron-specific
enolase and anti-synaptophysin antibodies. Neither mitoses nor ganglioid cells were seen. HNK1, the three isoforms of NCAM,
and the L1 adhesion molecule were detected by Western blot analysis. Ultrastructural study showed three different types of
cells. The first contained gliofilaments, the second showed long processes with true synapses, and the third was poorly differentiated.
However, all had identical nuclei and contained dense bodies. These findings suggest a common origin for the tumour cells
derived from a bipotential neuroglial progenitor. As for other mature mixed neuroglial tumours, the prognosis is good. Our
patient is free of disease 7 years after complete surgical treatment.
Received: 17 May 1999 / Revised, accepted: 21 July 1999 |
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Keywords: | Papillary Glioneuronal tumour Electron microscopy NCAM L1 adhesion molecule |
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