| 玫瑰糠疹皮损血管细胞黏附分子-1的检测 |
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| 引用本文： | 胡玉贤,王爱学,李玉平,四荣联,张贵贞. 玫瑰糠疹皮损血管细胞黏附分子-1的检测[J]. 中国皮肤性病学杂志, 2007, 21(7): 395-396 |
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| 作者姓名： | 胡玉贤 王爱学 李玉平 四荣联 张贵贞 |
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| 作者单位： | 河北医科大学第二医院皮肤科,河北,石家庄,050000 |
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| 摘 要： | 目的探讨血管细胞黏附分子-1(VCAM-1)在玫瑰糠疹中的发病机制。方法采用免疫组化SP法检测玫瑰糠疹皮损血管内皮细胞VCAM-1的表达。结果皮损组血管内皮细胞VCAM-1的表达均高于正常皮肤组及玫瑰糠疹皮损周围正常皮肤组,玫瑰糠疹皮损周围正常皮肤组的表达高于正常皮肤组,差异均有显著性(P<0.05)。结论VCAM-1在玫瑰糠疹皮损血管内皮细胞上的高表达与真皮浅层血管周围淋巴细胞浸润有关,参与了玫瑰糠疹的炎症反应。
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| 关 键 词： | 玫瑰糠疹 皮损 血管细胞黏附分子-1 |
| 文章编号： | 1001-7089（2007）07-0395-02 |
| 收稿时间： | 2007-01-31 |
| 修稿时间： | 2007-01-312007-03-22 |
Detection of VCAM-1 in Skin Lesions of Pityriasis Rosea |
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| HU Yu-xian, WANG Ai-xue, LI Yu-ping, et al. Detection of VCAM-1 in Skin Lesions of Pityriasis Rosea[J]. The Chinese Journal of Dermatovenereology, 2007, 21(7): 395-396 |
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| Authors: | HU Yu-xian WANG Ai-xue LI Yu-ping et al |
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| Affiliation: | Department of Dermatology, the Second Affiliated Hospital, Hebei Medical University, Shijiazhuang 050000, China |
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| Abstract: | Objective To study the pathogensis and mechanism of pityriasis rosea by detecting the expression of VCAM-1.Methods The expression of VCAM-1 on the endotheliocytes of blood vessels of the skin lesions was detected by immunohistochemistry.Results The resultes showed that the expression of VCAM-1 on the endotheliocytes of blood vessels in the lesions was higher than that around the lesions as well as in the normal skin.Besides, the expression of VCAM-1 on the endotheliocytes of blood vessels around the lesion was also higher than that in the normal skin (P<0.05).Conclusion The higher expression of VCAM-1 on the endotheliocytes in pityriasis rosea lesions is related to the infiltration of lymphocytes.VCAM-1 on the endotheliocytes has participated in the inflammatory response in pityriasis rosea. |
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| Keywords: | Pityriasis rosea Skin leisions VCAM-1 |
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