速效抗晕胶囊各组分毒性相互作用研究

目的 观察速效抗晕胶囊的3种组份硫酸右旋苯丙胺、茶苯海明和干姜提取物的毒性相互作用类型,评价药物的安全性.方法 用综合计算法评价速效抗晕胶囊3种原料硫酸右旋苯丙胺、茶苯海明和干姜提取物灌胃的小鼠急性半致死剂量(LD50),测试硫酸右旋苯丙胺、茶苯海明和干姜提取物两两及三者按组方比例联用的小鼠急性毒性LD50,用Finney法评价药物联用毒性相互作用的类型.结果 灌胃给药后ICR小鼠的硫酸右旋苯丙胺、茶苯海明及干姜提取物LD50分别为154.0、627.6 mg/kg及大于24 g/kg,硫酸右旋苯丙胺-茶苯海明、硫酸右旋苯丙胺-干姜提取物、茶苯海明-干姜提取物、硫酸右旋苯丙胺-茶苯海明-干姜提取物按组方比例联用的LD50分别为529.9、1834.0、110.4、1043.3 mg/kg;Finney法评价上述组合联用后毒性相互作用的Q值分别为0.93、0.87、1.10、0.88,速效抗晕胶囊3组份的4种组合毒性相互作用类型均为相加作用.结论 组成速效抗晕胶囊的硫酸右旋苯丙胺、茶苯海明和干姜提取物的毒性相互作用的类型为毒性相加作用,无协同增加药效的毒性现象.

Research on the toxic interaction of components in the quick-acting anti-motion sickness capsule

Objective To observe the toxic interaction of the 3 components (dextroamphetamine sulfate,dimenhydrimate and ginger extract) in the quick-acting anti-motion sickness capsule and evaluate safety of the drug. Methods LD50 of dextroamphetamine sulfate,dimenhydrimate,ginger extract and different combinations (i. e. dextroamphetamine sulfate-dimenhydrimate,dextroamphetamine sulfate-ginger extract,dimenhydrimate-ginger extract or dextroamphetamine sulfate-dimenhydrimate-ginger extract) were studied by using ICR mice. The interactive effects of the above combinations were determined with the Finney model.Results LD50 of dextroamphetamine sulfate,dimenhydrimate and ginger extract were 154.0 mg/kg,627.6 mg/kg and more than 24 g/kg. LD50 of dextroamphetamine sulfate-dimenhydrimate,dextroamphetamine sulfateginger extract,dimenhydrimate-ginger extract and dextroamphetamine sulfate-dimenhydrimate-ginger extract were evaluated to be 529.9 mg/kg,1834.0 mg/kg,1110.4 mg/kg and 1043.3 mg/kg respectively. Results showed that Q values of dextroamphetamine sulfate-dimenhydrimate,dextroamphetamine sulfate-ginger extract,dimenhydrimate-ginger extract and dextroamphetamine sulfate-dimenhydrimate-ginger extract were 0.93,0. 87,1.10 and 0. 88 respectively by using the Finney model. The interaction of the 4 combinations of the 3 components in the quick-acting anti-motion sickness capsule proved to be additive. Conclusions The toxic interaction of the 4 components ( dextroamphetamine sulfate,dimenhydrimate and ginger extract) in the quickacting anti-motion sickness capsule proved to be additive,rather than synergetic.