| 眼球运动联合平衡功能测试对帕金森病和进行性核上性麻痹的鉴别诊断价值 |
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| 引用本文： | 孙卓 钟文 周银平 王含 陈霞. 眼球运动联合平衡功能测试对帕金森病和进行性核上性麻痹的鉴别诊断价值[J]. 神经疾病与精神卫生, 2019, 19(1): 21-24 |
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| 作者姓名： | 孙卓 钟文 周银平 王含 陈霞 |
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| 作者单位： | 中国医学科学院北京协和医学院北京协和医院临床药理研究中心;中国医学科学院北京协和医学院北京协和医院协和转化医学中心;中国医学科学院北京协和医学院北京协和医院神经内科;创制药临床PKPD研究北京市重点实验室;首都医科大学附属北京天坛医院国家神经系统疾病临床医学研究中心临床试验中心 |
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| 基金项目： | 国家自然科学基金面上项目（81673169）；国家“十三五”重大新药创制专项基金资助项目（2017ZX09304031-001）；国家“十三五”重点研发计划项目（2016YFC0105904XHW） |
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| 摘 要： | 目的观察比较帕金森病(PD)和进行性核上性麻痹(PSP)患者的眼球运动和平衡特点。方法采用横断面调查研究方法,顺序人组PD和PSP患者,对患者进行眼球水平运动和躯体摆动测试,收集测试结果并比较组间以及与健康对照之间测试结果的差异。结果人组18例PD患者[男11例,年龄67(60,71)岁],9例PSP患者[男7例,年龄74(66,78.5)岁]和44名健康人[男15名,年龄67.5(62,71)岁]。分层回归分析结果提示,在控制了年龄和性别的潜在影响后,眼动指标和躯体摆动指标在健康人和PD患者间的差异有统计学意义(P﹤0.01),眼动指标在健康人和PSP患者间的差异有统计学意义(P﹤0.01),躯体摆动指标在健康人和PSP患者间的差异无统计学意义CP﹥0.05),眼动指标和躯体摆动指标在PD患者和PSP患者间的差异无统计学意义(P﹥0.05)。结论眼动和躯体摆动指标相结合或许有助于鉴别PD和PSP。
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| 关 键 词： | 帕金森综合征 帕金森病 进行性核上性麻痹 眼球运动 躯体摆动 |
Value of differential diagnosis of the combination of eye movement and body sway examination onParkinson disease and progressive supranuclear paralysis |
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| Sun Zhuo,Zhong Wen,Zhou Yinping,Wang Han,Chen Xia. Value of differential diagnosis of the combination of eye movement and body sway examination onParkinson disease and progressive supranuclear paralysis[J]. Nervous Diseases and Mental Health, 2019, 19(1): 21-24 |
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| Authors: | Sun Zhuo Zhong Wen Zhou Yinping Wang Han Chen Xia |
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| Affiliation: | (Clinical Pharmacological Research Center,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China;Union Translational Medical Center,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China;Neurology Department,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China;Beijing Key Laboratory of Clinical PK and PD Investigation for Innovative Drugs,Beijing 100195,China;Clinical Trial Center,Capital Medical University China National Clinical Research Center for Neurological Disease,Beijing Tiantan Hospital,Beijing 100070.China) |
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| Abstract: | Sun Zhuo;Zhong Wen;Zhou Yinping;Wang Han;Chen Xia(Clinical Pharmacological Research Center,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China;Union Translational Medical Center,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China;Neurology Department,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China;Beijing Key Laboratory of Clinical PK and PD Investigation for Innovative Drugs,Beijing 100195,China;Clinical Trial Center,Capital Medical University China National Clinical Research Center for Neurological Disease,Beijing Tiantan Hospital,Beijing 100070.China) |
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| Keywords: | Parkinsonism Parkinson disease Progressive supranuclear palsy Eye movement Body sway |
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