EFNB2基因多态性与精神分裂症的相关性以及microRNA-137在其中的作用探讨

目的 研究EFNB2基因rs550067317位点单核苷酸多态性与精神分裂症的相关性以及microRNA-137(miR-137)在其中的作用探讨。方法 随机选择2015年8月-2017年12月期间我院收治的85例精神分裂症患者作为研究组,85例健康体检者作为对照组。分析所有受试者EFNB2基因rs550067317位点基因型以及血浆中miR-137水平。结果 研究组患者EFNB2基因rs550067317位点C等位基因是精神分裂症发生的保护因素(OR=0.413, 95%CI=0.226-0.750, P=0.002)。野生型受试者血浆miR-137水平显著高于突变型,差异有统计学意义(P<0.01)。miR-137诊断精神分裂症的AUC为0.8619(P<0.0001),敏感度为72.94%,特异度为85.88%,cut-off值为2.45。结论 EFNB2基因rs550067317位点基因多态性与精神分裂症风险相关,血浆miR-137水平检测精神分裂症具有较高的诊断价值。

Correlation between EFNB2 gene polymorphism and the risk of schizophrenia and the role of microRNA-137.

Objective To study the relationship between single nucleotide polymorphism (SNP) of EFNB2 gene EFNB2 gene rs550067317 locus and risk of schizophrenia and the role of microRNA-137 (miR-137) in it. Methods Eighty-five patients with schizophrenia admitted to our hospital from August 2015 to December 2017 were selected as the study group, and 85 healthy subjects were used as the control group. EFNB2 gene rs550067317 genotype and the plasma miR-137 levels were analyzed. Results The C allele of the rsNB067317 locus in the study group was a protective factor for schizophrenia (OR=0.413, 95% CI=0.226-0.750, P=0.002). Plasma miR-137 levels were significantly higher in wild-type subjects than in mutants, and the difference was statistically significant (P<0.01). The AUC of miR-137 for the diagnosis of schizophrenia was 0.8619(P < 0.0001), sensitivity was 72.94%, specificity was 85.88%, and cut-off value was 2.45. Conclusion The polymorphism of EFNB2 gene rs550067317 is associated with the risk of schizophrenia. Detection of plasma miR-137 levels has a high diagnostic value for schizophrenia.