| 环状RNA与心血管衰老及心血管病的研究进展 |
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| 引用本文： | 凌浩,张艳秋,杨闯,肖钰,廉瑞,宋春莉. 环状RNA与心血管衰老及心血管病的研究进展[J]. 中国心血管病研究杂志, 2019, 17(2) |
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| 作者姓名： | 凌浩 张艳秋 杨闯 肖钰 廉瑞 宋春莉 |
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| 作者单位： | 吉林大学第二医院,吉林大学第二医院,吉林大学第二医院,吉林大学第二医院,吉林大学第二医院,吉林大学第二医院 |
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| 基金项目： | 吉林省教育厅十三五科学技术研究项目（JJKH20180104KJ）；吉林省财政厅卫生专项项目（2017年）；吉林省新型冠脉支架科技创新中心（JKFC2017250) |
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| 摘 要： | 环状RNA（circRNA）具有与线性RNA完全不同的共价闭环结构，在哺乳动物组织中普遍表达, 在心血管领域，circRNA已被证明具有抗心血管衰老、与RNA结合蛋白结合作为microRNA海绵、作为生物标志物及作为疾病治疗的靶点等多种功能。本文综述了近年来环状RNA与心血管衰老及circRNA在心血管病作用的研究进展。
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| 关 键 词： | 环状RNA；衰老；心血管病 |
| 收稿时间： | 2018-12-03 |
| 修稿时间： | 2019-01-11 |
The research Progress in circular RNA and cardiovascular aging and cardiovascular diseases |
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| zhangyanqiu,yangchuang,xiaoyu,lianrui and songchunli. The research Progress in circular RNA and cardiovascular aging and cardiovascular diseases[J]. Chinese Journal of Cardiovascular Review, 2019, 17(2) |
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| Authors: | zhangyanqiu yangchuang xiaoyu lianrui songchunli |
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| Abstract: | circRNA have covalent closed-loop structures completely different from linear RNA, which are widely expressed in mammalian tissues. In the field of cardiovascular diseases, circRNA have been proven to have anti-cardiovascular aging, bind with RNA binding proteins as microRNA sponges, serve as biomarkers and serve as targets for disease treatment, etc. This paper reviews the recent progress in the research on the role of circrnas in cardiovascular aging and circRNA in cardiovascular diseases. |
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| Keywords: | Circular RNA aging cardiovascular disease |
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