胰岛素强化治疗在初发2型糖尿病患者中临床应用的效果分析

目的探究胰岛素强化治疗在初发2型糖尿病患者中临床应用效果。方法选择2018年5月—2019年12月该院收治的100例初发2型糖尿病患者,按入院的先后顺序分为实验组和对照组,每组50例。对照组采用口服降糖药治疗,实验组采用胰岛素强化治疗,对比两组患者的血糖指标,治疗效果以及空腹胰岛素(Fins),胰岛β细胞功能指数(HOMA-β)和胰岛素抵抗指数(HOMA-IR)。结果(1)治疗后两组患者的FPG、2 hPG、HbA1c较治疗前均降低,差异有统计学意义(P<0.05),且采用胰岛素强化治疗的实验组的FPG(6.11±1.33)mmol/L,2 hPG(8.64±1.55)mmol/L,HbA1c(6.13±0.36)%均低于对照组,差异有统计学意义(P<0.05)。(2)实验组患者的低血糖发生率4%、胰岛素用量(43.16±8.83)IU/d和血糖达标时间(4.28±1.45)d均少于对照组,差异有统计学意义(P<0.05)。(3)治疗后两组患者的Fins、HOMA-β较治疗前增加,HOMA-IR降低,差异有统计学意义(P<0.05),且实验组的Fins(8.26±2.37)mU/L、HOMA-β(54.46±13.41)比对照组明显增加,HOMA-IR(2.27±0.82)比对照组减少,差异有统计学意义(P<0.05)。结论胰岛素强化治疗在初发2型糖尿病患者的临床治疗中效果显著,可短期内降低血糖,改善患者生活质量,值得在临床推广应用。

Effect Analysis of Clinical Application of Insulin Intensive Therapy in Newly Diagnosed Type 2 Diabetes Patients

Objective To explore the effect of intensive insulin therapy in patients with newly diagnosed type 2 diabetes.Methods A total of 100 patients with newly diagnosed type 2 diabetes admitted to the hospital from May 2018 to December2019 were divided into experimental group and control group according to the order of admission,with 50 cases in each group.The control group was treated with oral hypoglycemic drugs,and the experimental group was treated with insulin intensive treatment.The blood glucose index,treatment effect and fasting insulin(Fins),isletβcell function index(HOMA-β)and insulin resistance index(HOMA-IR)were compared between the two groups.Results 1.FPG,2 hPG and HbA1c of the two groups of patients after treatment were all lower than before treatment,the difference was statistically significant(P<0.05)and the experimental group with insulin intensive treatment had FPG(6.11±1.33)mmol/L,2 hPG(8.64±1.55)mmol/L and HbA1c(6.13±0.36)%were lower than those of the control group,the difference was statistically significant(P<0.05).2.The incidence of hypoglycemia of 4%,insulin dosage(43.16±8.83)IU/d and blood glucose reaching time(4.28±1.45)d in the experimental group were lower than those in the control group,the difference was statistically significant(P<0.05).3.Fins and HOMA-βof the two groups of patients after treatment increased compared with before treatment,HOMA-IR decreased,the difference was statistically significant(P<0.05),and the Fins(8.26±2.37)mU/L,HOMA-β(54.46±13.41)of the experimental group were compared with the control group,HOMA-IR(2.27±0.82)was significantly increased compared with the control group,the difference was statistically significant(P<0.05).Conclusion Intensive insulin therapy has a significant effect in the clinical treatment of patients with newly diagnosed type 2 diabetes.It can reduce blood glucose in a short time,improve the quality of life of patients.It is worthy of clinical application.