粪菌移植联合乳果糖口服液治疗老年功能性便秘患者临床疗效观察及对胃肠激素水平影响

目的：探讨粪菌移植联合乳果糖口服液治疗老年功能性便秘患者临床疗效观察及对胃肠激素水平影响。方法：选择我院于2017年1月至2018年9月期间收治的老年功能性便秘患者103例作为研究对象,按照随机表法分为观察组52例与对照组51例。对照组患者采用乳果糖口服液治疗,观察组在对照组基础上结合粪菌移植治疗。两组疗程均为6周。比较两组治疗疗效和胃肠功能变化,治疗前后大便异常评分和胃肠激素水平变化。结果：观察组总有效率(94.23%)高于对照组(74.51%)(P<0.05)。两组肠鸣音恢复时间、首次自主排便时间和肛门首次排气时间快于对照组(P<0.05)。两组治疗后大便异常评分较治疗前降低(观察组：t=30.890,对照组：t=20.479,P<0.05)；观察组治疗后大便异常评分低于对照组(t=16.657,P<0.05)。两组治疗后血清SP水平较治疗前升高,而MTL水平较治疗前降低(观察组：t=13.780、22.718,对照组：t=7.177、8.886,P<0.05)；观察组治疗后血清SP水平高于对照组,而MTL水平低于对照组(t=7.380、11.638,P<0.05)。结论：粪菌移植联合乳果糖口服液治疗老年功能性便秘患者临床疗效良好,可改善患者胃肠激素水平,值得临床借鉴。

Clinical observation of fecal bacteria transplantation combined with lactulose oral liquid in the treatment of elderly patients with functional constipation and its effect on gastrointestinal hormone levelYe Jietong Lishui People

Objective: To investigate the clinical effect of fecal bacteria transplantation combined with lactulose oral liquid in the treatment of Senile Functional Constipation and its effect on gastrointestinal hormone level. Methods: 103 elderly patients with functional constipation admitted to our hospital from January 2017 to September 2018 were selected as the research objects. According to the random table method, 52 cases in the observation group and 51 cases in the control group were divided into two groups. The patients in the control group were treated with lactulose oral liquid, while the patients in the observation group were treated with fecal bacteria transplantation on the basis of the control group. Both groups were treated for 6 weeks. The therapeutic effect and gastrointestinal function were compared between the two groups. The score of abnormal stool and the level of gastrointestinal hormones before and after treatment were compared. Results: The total effective rate of the observation group (94.23%) was higher than that of the control group (74.51%) (P<0.05). The recovery time of bowel sounds, the first time of voluntary defecation and the first time of anal exhaust in the two groups were faster than those in the control group (P<0.05). After treatment, the score of abnormal stool in the two groups was lower than that before treatment (observation group:t=30.890, control group:t=20.479, P<0.05); after treatment, the score of abnormal stool in the observation group was lower than that in the control group (t=16.657, P<0.05). After treatment, the serum SP level of the two groups was higher than that before treatment, while the MTL level was lower than that before treatment (observation group:t=13.780, 22.718, control group:t=7.177, 8.886, P<0.05); after treatment, the serum SP level of the observation group was higher than that of the control group, while the MTL level was lower than that of the control group (t=7.380, 11.638, P<0.05). Conclusion: Fecal bacteria transplantation combined with lactulose oral liquid has good clinical efficacy in the treatment of elderly patients with functional constipation, and can improve the level of gastrointestinal hormones, which is worthy of clinical reference.