| Abstract: | AIM: To study clinical effectiveness and immunocorrective properties of polyoxidonium in chronic alcoholics with renal impairment. MATERIAL AND METHODS: The trial enrolled 62 chronic alcoholics with chronic pyelonephritis (CP). Group 1 comprised 28 patients (mean age 39.9 +/- 2.4 years) with severe chronic alcoholism (CA) in long abstinence and grave CP; 16 moderate CA patients of group 2 (mean age 42.2 +/- 1.2 years) with moderate CP in drinking period; the control group consisted of 11 severe CA patients (mean age 39.2 +/- 1.2 years) in short-term abstinence and moderate CP. CP was the only visceral damage in the examinees. All the patients were examined clinically. Biochemical blood tests, ultrasound, x-ray examinations, radionuclide investigation of the kidneys, immunological examination were made before and after the treatment. Patients of groups 1 and 2 received polyoxidonium (12 mg once a day, i.m., each other day, a course dose 0.084 g) in combination with penicillin and nistatin. Patients of group 3 received placebo in combination with the same antibacterial therapy. RESULTS: Remission with normalization of laboratory and immunological parameters was achieved in 75% of group 1 patients. No response was seen in 7.1%. In group 2 remissions were absent while immunological changes were insignificant. Group 3 patients exhibited clinical response in 48.2% but no remission was achieved. CONCLUSION: Polyoxidonium immunocorrection was effective in CA patients with renal affection only in long-term abstinence being a failure in drinking period. |
