晚期宫颈癌患者同步放化疗前后证候变化的临床研究

目的:观察晚期宫颈癌患者同步放化疗前后证候变化。方法:采用前瞻性和回顾性相结合的流行病学研究方法,对诊断晚期宫颈癌初次接受放化疗的患者进行放化疗前后证候病机变化的对照研究。结果:①临床各证型(肝郁气滞、肝肾阴虚、脾肾阳虚、湿热瘀毒)放化疗前与首次放化疗后1周、第2次放化疗后1周、首次放化疗后3个月、第2次放化疗后3个月的证候构成比比较,差异均有显著性意义(P0.05)。②晚期宫颈癌患者放化疗前后面色变化比较,面色白放化疗治疗后各时间调查点与放化疗治疗前比较,差异有显著性意义(P0.05)。③晚期宫颈癌患者放化疗前后舌色变化观察,舌质(淡红、红、黯红、淡白、淡黯)、舌苔(薄白苔、白腻苔、白厚苔、黄腻苔、剥少苔)构成比放化疗前与首次放化疗后1周、第2次放化疗后1周、首次放化疗后3个月、第2次放化疗后3个月相比较,差异均有显著性意义(P0.05)。结论:同期放化疗前后各证型不同,则舌质、舌苔的变化也不同,可为临床治疗提供参考依据。

Clinical Effect of TCM Syndrome Type Change of Concurrent Radiotherapy and Chemotherapy in Patients with Advanced Cervical Cancer

Objective：To observe the TCM syndrome type change of concurrent radiotherapy and chemotherapy in patients with advanced cervical cancer.Methods：Uses forward-looking and the review disposition union epidemiology research technique,to diagnoses the patient with advanced cervical cancer who first accepts for the concurrent radiotherapy and chemotherapy of the TCM syndrome type pathogenesis change comparison research.Results：①The type1,the liver depressed and Qi stagnation stasis（Gan You Qi Zhi）,The type2,the liver and kidney ying stasis（Gan Sheng ying Xue）,The type3,the spleen and kidney yang stasis（Pi Sheng yang Xue）,The type4,the dampness and heat and Blood stasis（Shi Rei Yu Du）,Compared with before of radiotherapy and chemotherapy treatment,the first time puts radiotherapy and chemotherapy latter 1 week,the second time puts radiotherapy and chemotherapy latter 1 week,puts for the first time radiotherapy and chemotherapy latter 3 months,puts for the second time radiotherapy and chemotherapy latter 3 months,respectively,showing significant improvement（P0.05）.②Compared with the 5 investigation point time patient with advanced cervical cancer facial color change,The pale color showing significant improvement（P0.05）.③Compared with the 5 investigation point time patient with advanced cervical the tongue substance（pale red,red,dark red,pale,pale dark）and the tongue coating（thin Bai Tai,white greasy fur,Bai Houtai,yellow greasy fur,exhausted few liver mosses）change showing significant improvement too（P0.05）.Conclusion：Different Variations of the tongue substance and the tongue coating indexes present in advanced cervical cancer of different syndrome types,there are certain relationship between the TCM syndrometypes and the tongue substance and the tongue coating indexes,and these rules may provide reference for evaluating clinical therapeutic effects.