Caspase介导的Fas凋亡途径

凋亡是导致细胞死亡的调节性生理过程.Fas在各种疾病和细胞凋亡的发生中起到首要作用.Caspase为半胱氨酸蛋白酶家族,是凋亡的中心调节者,一旦Caspase-8,10被激活,引起Caspase的断裂及激活下游的Caspase-3,6,7,作用于Bcl-2家族某些成员如Bad、一些骨架蛋白和RB蛋白等并使其断裂,从而导致细胞凋亡.本文重点讨论了Caspase-3,-8的激活机制及其在Fas诱导细胞凋亡中的作用.

Caspase-mediated Fas apoptotic pathway

Apoptosis is a regulated physiological process leading to cell death. Fas play a pivotal role in the pathogenesis of various diseases and cell apoptosis. Caspases, a family of cystenie acid proteases, are central regulators of apoptosis. Once Caspase-8 and Caspase-10 are activated, these Caspases cleave and the downstream Cas- pases including Caspase-3, -6 and -7 are activat- ed, which in turn cleave cytoskeletal and nuclear proteins like RB and Bad, further resulting in cell apoptosis. In this article, we discussed the mechanisms of Caspase-3, -8 activation and their roles in Fas-induced cell apoptosis.