| 抗疟药咯萘啶与磺胺多辛及乙胺嘧啶配伍治疗恶性疟结果的分析 |
| |
| 引用本文： | 陈昌,蔡贤铮,车立刚,陈怀录,蒋妙根. 抗疟药咯萘啶与磺胺多辛及乙胺嘧啶配伍治疗恶性疟结果的分析[J]. 寄生虫病与感染性疾病, 1997, 0(3) |
| |
| 作者姓名： | 陈昌 蔡贤铮 车立刚 陈怀录 蒋妙根 |
| |
| 作者单位： | 中国预防医学科学院寄生虫病研究所!上海，200025，海南省热带病防治研究所!海口，570203，云南省疟疾防治研究所!思茅，665000，四川省寄生虫病防治研究所!成都，610041，浙江省卫生防疫站!杭州，310009 |
| |
| 摘 要： | 本文对咯萘啶与磺胺多辛和乙胺嘧啶配伍，多年来在海南和云南的抗药性地区治疗恶性疟的结果进行综合分析，认为这种配伍不宜用于抗药性恶性疟地区的防治。因为：（1）未能明显地延缓恶性疟原虫对该种伍用产生抗药性，纵向监测于用药8年后，出现RⅢ病列，药后24h的减虫率明显下降（P＜0．05）；（2）恶性疟治疗后28d，60％左右的病例仍携带配子体，经大劣按蚊和微小按蚊血餐后，在诞腺中可查见子孢子，表明此种配伍治疗后，会引起恶性疟的传播与扩散。
|
| 关 键 词： | 咯萘啶与磺胺多辛和乙胺嘧啶配伍 恶性疟 抗药性 配子体 子孢子 |
ANALYSIS ON RESULTS OF ANTIMALARIAL PYRONARIDINE COMBINED WITH SULFADOXINE AND PYRIMETHAMINE TO FALCIPARUM MALARIA |
| |
| Chen Chang et al. ANALYSIS ON RESULTS OF ANTIMALARIAL PYRONARIDINE COMBINED WITH SULFADOXINE AND PYRIMETHAMINE TO FALCIPARUM MALARIA[J]. Parastoses and Infectious Diseases, 1997, 0(3) |
| |
| Authors: | Chen Chang et al |
| |
| Abstract: | The peper presents a synthesis of the results for the treatment of falciparum malaria by pyronaridine combined with sulfadoxine and pyrimethamine in Hainan and Yunnan areas. for many years. It could not evidently reard the progress of resistance to the triple combination which was used on trial to treat falciparum malaria. There were about 60% of patients with gametocytes on 28th day after treatment with the combination. The sporozoites were found in the salivary gland of Anopheles dirus and An. minimus after blood meal. It showed that the triple combination in the treatment of falciparum malaria did not break down the spread and transmission of falciparum malaria. |
| |
| Keywords: | Pyronaridine combined with sulfadoxine and pyrimethamine falciparum malaria drug-resistance gametocyte sporozite |
| 本文献已被 CNKI 等数据库收录！ |
