Microencephaly in children congenitally infected with human immunodeficiency virus – a gross-anatomical morphometric study |
| |
Authors: | P B Kozlowski J Brudkowska M Kraszpulski E A Sersen M A Wrzolek A P Anzil C Rao H M Wisniewski |
| |
Institution: | (1) Clinical Neuropathology, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA Fax: 1-718-494-5347, IS;(2) Staten Island University Hospital, Staten Island, New York, USA, IS;(3) Kings County Hospital Center/State University of New York Health Science Center at Brooklyn, New York, USA, US |
| |
Abstract: | A quantitative technique involving serial sectioning and semiautomatic morphometric analysis was used to assess the severity
of the reduction in size of the major brain structures in cerebral hemispheres of children congenitally infected with HIV-1.
Cerebral hemispheres from 12 children (18–48 months of age) who died of AIDS were sectioned into 5-mm-thick serial slabs and
photographed. The cross-sectional areas of grossly recognizable brain structures were digitized, and the volumes were calculated
according to Cavalieri’s principle. The results were compared with those of an identically processed group of control brains
from non-AIDS children. Analysis of the brain weight showed that there was a significant reduction in supratentorial and infratentorial
weight in the AIDS group. The results of the morphometric study revealed that the loss in brain mass was associated with a
statistically significant reduction in the total volume of both hemispheres, the entire cortex, white matter, and basal ganglia.
Detailed analysis of individual brain structures also showed a significant reduction in volume of all cortical regions and
most of the subcortical gray matter (e.g., caudate nucleus, putamen, globus pallidus, claustrum, and thalamus). It appears
that in the microencephaly observed as a frequent sequel in pediatric AIDS, the loss of brain tissue is global and includes
an almost proportional loss of cortex, subcortical gray matter and white matter.
Received: 18 July 1995 / Revised: 17 July 1996 / Accepted: 22 August 1996 |
| |
Keywords: | Pediatric AIDS Microencephaly Morphometry Cavalieri’ s principle |
本文献已被 SpringerLink 等数据库收录! |
|