Vaccination against spontaneous abortion in mice |
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Authors: | G Chaouat N Kiger T G Wegmann |
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Institution: | 1. Unité 255, INSERM Fondation Curie, 26 rue d''Ulm, Paris 75231, Paris Cedex 05, France;2. Unité 210, INSERM, Laboratoire d''Immunologie, CHU de Nice, Nice, France |
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Abstract: | We report here that the high rate of spontaneous resorption observed in CBA/J female mice mated with DBA/2 J males can be dramatically reduced by vaccination with Balb/c male spleen cells, but not by CBA/J or DBA/2 J male spleen cells. This effect correlates with the differential ability of Balb/c spleen cells to induce MLR suppressor activity in CBA/J female mice, and should lead to a better understanding of the immunology of the materno-fetal relationship. |
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