妊娠高血压综合征患者不同尿蛋白排泄状态下血浆蛋白和血脂代谢特点

目的探讨妊娠高血压综合征（PIH）患者不同尿蛋白排泄状态下血浆蛋白和血脂代谢特点，了解血浆蛋白和血脂代谢紊乱与尿蛋白的关系。方法将125例PIH患者根据24h尿蛋白定量分成3组：轻度蛋白尿组30例，尿蛋白0．1～0．5g；中度蛋白尿组59例：尿蛋白0．5～4g；重度蛋白尿组36例：尿蛋白≥4g。同时选择无妊娠合并症的健康孕妇43例作为正常妊娠组。检测总蛋白（TP）、清蛋白（ALB）、总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白（HDL—C）、低密度脂蛋白（LDL—C）。结果3组血浆蛋白和血脂水平与对照组比较均有显著性差异（P〈0．01），且重度蛋白尿组血浆蛋白水平显著低于轻、中度蛋白尿组，而血脂水平显著高于轻、中度蛋白尿组。结论PIH患者随着蛋白尿程度不断加重低蛋白血症、高脂血症表现也越来越突出，应加强血浆蛋白和血脂监测，及早干预并纠正以保证母婴健康。

Characteristics of plasma protein and lipids metabolism under different proteinuria profilings in the patients with pregnancy induced hypertension

Objective ： To study the characteristics of plasma protein and lipids metabolism under different proteinuria profilings in the patients with pregnancy induced hypertension （PIH）. Methods： 125 patients with PIH were divided into 3 groups： the micro - proteinuria group 0. 1g≤24 hour urine protein （24h UPr） 〈0. 5g, 30 cases], the medium - proteinuria group 0.5g≤24 h UPr 〈 4g, 59 cases] and macro- proteinuria group 24h UPr ≥4g, 36 cases] . The plasma levels of Total protein （TP）, Albumin （ ALB）, Total cholesterol （ TC）, Triglyceride （ TG）, High - density lipoprotein （ HDL - C ）, Low - density lipoprotein （ LDL - C） and 24 h Upr were detected in HITACHI 7600 analyzer. Results： There were significant difference in all parameters except HDL - C between PIH and control group （ P 〈 0. 01 ）. ANOVA analysis showed significant difference in all parameters between macro - PIH and micro, medium- PIH groups （ P 〈 0.01 ）. Conclusion： The present results indicated that the PIH patients had more serious disorder of plasma protein and lipids metabolism with increasing proteinuria. It was suggested to analyze plasma protein and lipids in time for preventing some syndrome.