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Successful treatment of bilateral endogenous Fusarium solani endophthalmitis in a patient with acute lymphocytic leukaemia |
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| Authors: | Ilaria Rizzello Fausto Castagnetti Pier Giorgio Toschi Patrizia Bertaccini Laura Primavera Michela Paolucci Luca Faccioli Luca Spinardi Russell E Lewis Michele Cavo Marta Stanzani |
| Institution: | 1. Institute of Hematology “Lorenzo e Ariosto Seràgnoli”, Department of Specialistic Diagnostic and Experimental Medicine (DIMES), Sant'Orsola‐Malpighi Hospital Teaching Hospital, University of Bologna, Bologna, Italy;2. Ophthalmology Unit, Department of Specialistic Diagnostic and Experimental Medicine (DIMES), Sant'Orsola‐Malpighi Teaching Hospital, University of Bologna, Bologna, Italy;3. Unit of Clinical Microbiology, Department of Specialistic Diagnostic and Experimental Medicine (DIMES), Sant'Orsola‐Malpighi Teaching Hospital, University of Bologna, Bologna, Italy;4. Diagnostic and Interventional Neuroradiology, Department of Head, Neck and Sense Organs, Sant'Orsola‐Malpighi Teaching Hospital, University of Bologna, Bologna, Italy;5. Department of Medical and Surgical Sciences (DIMEC), Clinic of Infectious Diseases, Sant'Orsola‐Malpighi Teaching Hospital, University of Bologna, Bologna, Italy |
| Abstract: | Fusarium spp. are an uncommon cause of fungaemia in immunocompromised and neutropenic patients that may hematogenously disseminate to the eyes. Herein, we describe a patient with acute lymphoblastic leukaemia and a prior history of extensive corticosteroid exposure who developed disseminated Fusarium solani infection following chemotherapy despite posaconazole prophylaxis. She was successfully treated with combination liposomal amphotericin B and voriconazole, intraocular injections of voriconazole, topical amphotericin B and bilateral vitrectomy. We also review published literature describing the management of endogenous Fusarium endophthalmitis in immunocompromised hosts. |
| Keywords: | antifungal therapy endophthalmitis fungal infection haematology vitrectomy voriconazole |