| Over-expression of EGFR in Breast Cancer |
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| 作者姓名： | 薄爱华 侯金超 兰永昊 田亚汀 张俊岩 |
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| 作者单位： | Hebei North University, Zhangjiakou, 075029 |
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| 摘 要： | Objective： To explore the relationship of overexpression of epidermal growth factor receptor （EGFR） in occurrence, development and treatment of breast cancer. Methods： Samples of 46 breast adenoma tissues and 86 breast cancer tissues were regularly dehydrate-fixed, embedded in paraffin, sliced in to 5μm thick, stained with SABC immunohistochemistry and coloured with DAB. Results： The positive staining of EGFR was shown as brown- yellow and distributed in cytoplasm. The positive rates in the tissues of breast adenosis and breast cancer were 17.04% （6/46） and 56.98% （49/86） respectively. The positive rates of EGFR in the tissue of invasive ductal carcinoma was 64.49% （41/59）, which was significantly higher than that in in situ carcinoma （P〈0.05）. The positive rate of lymph metastasis group was higher than that in non-lymph metastasis group （P〈0.05）. Conclusion： The overexpression of EGFR was related with occurrence, lymph metastasis and pathologic types of breast cancer. The examination of EGFR in the breast cancer can serve as a guidance for target chemotherapy.
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| 关 键 词： | 乳腺肿瘤 癌症 表皮生长因子受体 免疫组织化学 |
| 文章编号： | 1000-9604（2008）01-0069-04 |
| 收稿时间： | 2007-04-06 |
| 修稿时间： | 2007-12-27 |
Over-expression of EGFR in breast cancer |
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| Ai-hua?Bo,Jin-chao?Hou,Yong-hao?Lan,Ya-ting?Tian,Jun-yan?Zhang.Over-expression of EGFR in Breast Cancer[J].Chinese Journal of Cancer Research,2008,20(1):69-72. |
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| Authors: | Ai-hua Bo Jin-chao Hou Yong-hao Lan Ya-ting Tian Jun-yan Zhang |
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| Institution: | (1) Hebei North University, Zhangjiakou, 075029, China |
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| Abstract: | Objective:To explore the relationship of overexpression of epidermal growth factor receptor(EGFR)in occurrence,development and treatment of breast cancer. Methods:Samples of 46 breast adenoma tissues and 86 breast cancer tissues were regularly dehydrate-fixed,embedded in paraffin,sliced in to 5 μm thick,stained with SABC immunohistochemistry and coloured with DAB. Results:The positive staining of EGFR was shown as brown- yellow and distributed in cytoplasm.The positive rates in the tissues of breast adenosis and breast cancer were 17.04%(6/46)and 56.98%(49/86)respectively.The positive rates of EGFR in the tissue of invasive ductal carcinoma was 64.49%(41/59),which was significantly higher than that in in situ carcinoma(P＜0.05).The positive rate of lymph metastasis group was higher than that in non-lymph metastasis group (P＜0.05). Conclusion:The overexpression of EGFR was related with occurrence,lymph metastasis and pathologic types of breast cancer.The examination of EGFR in the breast cancer can serve as a guidance for target chemotherapy. |
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| Keywords: | Breast adenoma Breast cancer Epidermal growth factor receptor (EGFR) Immunohistochemistry |
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