Use of human post-mortem cerebral blood vessels to study vasospasm |
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| Authors: | K Schr?r R Verheggen |
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| Affiliation: | 1. Department of Environmental Sciences, 400 Dowman Drive, 5th floor, Math & Science Center, Emory University, Atlanta 30322, GA, United States of America;2. Department of Entomology and Nematology, University of California, One Shields Ave., Davis, CA 95616, United States of America;3. Department of Biology, Lund University, Ecology Building, Sölvegatan 37, 223 62 Lund, Sweden;1. Departamento de Estatística and LACESM, Universidade Federal de Santa Maria, Brazil;2. Departamento de Matemática and LANA, Universidade Federal de Santa Maria, Brazil;3. Signal Processing Group, Departamento de Estatística, Universidade Federal de Pernambuco, Brazil;4. ECE, University of Calgary, Calgary, Canada;1. Department of Electrical and Electronic Engineering, Universiti Teknologi PETRONAS, 32610 Teronoh, Perak, Malaysia;2. Department of Physics, Kohat University of Science and Technology, Kohat, KPK, Pakistan;3. Department of Electrical Engineering, University of Engineering and Technology, Lahore, Pakistan;1. The James L. Winkle College of Pharmacy, The University of Cincinnati, United States;2. College of Engineering and Applied Science, The University of Cincinnati, United States;3. College of Arts & Sciences, Dept. of Chemistry, The University of Cincinnati, United States |
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| Abstract: | Although it is a major cause of death in patients with subarachnoid haemorrhage, little is known about the mechanisms involved in cerebral vasospasm. This is due to the difficulty in obtaining human tissue, and to wide differences between species in the response to vasoactive compounds. In this review, Karsten Schrör and Raphaela Verheggen discuss the evidence that the response of human cerebral blood vessels changes little during the first 24 h after death, and argue that samples obtained post-mortem provide a suitable model system to study vasospasm in vitro. |
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