| 放射治疗对鼻咽鳞癌P糖蛋白的影响 |
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| 引用本文： | 刘宇,张幸平,陈鸿雁,邓红彬,徐曼,李圆圆. 放射治疗对鼻咽鳞癌P糖蛋白的影响[J]. 重庆医科大学学报, 2004, 29(6): 786-788 |
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| 作者姓名： | 刘宇 张幸平 陈鸿雁 邓红彬 徐曼 李圆圆 |
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| 作者单位： | 重庆医科大学临床学院,肿瘤科,重庆,400016;重庆医科大学临床学院,耳鼻喉科,重庆,400016;重庆医科大学临床学院,重庆医科大学基础医学院病理教研室,重庆,400016 |
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| 摘 要： | 目的 :初步探讨鼻咽鳞癌多药耐药基因 (mdr - 1)产物p -糖蛋白 (pgp)在放疗前、后的表达及其临床意义。 方法 :应用免疫组化SP法单克隆抗体JSB - 1检测 4 8例初治的鼻咽鳞癌患者放疗前及放疗后 pgp的表达。 结果 :鼻咽鳞癌组织在放疗前pgp阳性表达率为 18.75 % (9/ 4 8) ,放疗后pgp阳性表达率为 75 .0 0 % (36 / 4 8)。放疗后pgp阳性率和放疗前相比有显著性差异 (P <0 .0 0 1)。结论 :放射治疗明显地诱导或加强鼻咽鳞癌组织中 pgp表达 ,这可能是引起放、化疗交叉耐药的原因之一。
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| 关 键 词： | 鼻咽癌/放射治疗 多药耐药性 P-糖蛋白 免疫组织化学 |
| 文章编号： | 0253-3626(2004)06-0786-03 |
| 修稿时间： | 2004-03-31 |
Effect of radiotherapy on P-glycoprotein expression in nasopharyngeal squamous carcinoma |
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| LIU Yu,et al. Effect of radiotherapy on P-glycoprotein expression in nasopharyngeal squamous carcinoma[J]. Journal of Chongqing Medical University, 2004, 29(6): 786-788 |
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| Authors: | LIU Yu et al |
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| Abstract: | Objective:To investigate preliminarily the expression of P-glycoprotein(pGp),a multi-drug resistance gene-1 product,in patients with nasopharyngeal squamous carcinoma(NPSC) before and after radiotherapy.Methods:pGp was detected by immunohistochemistry with one monoclonal antibody JSB-1 before and after radiotherapy in fourty-eight patients with NPSC.None of them had received neoadjuvant chemotherapy or radiotherapy.Results:The positive rate of pGp expression in the patients with NPSC before radiotherapy was 18.75%(9/48).But the positive expression rate of pGp after radiotherapy was 75.00%(36/48).pGp expression rate after radiotherapy was significantly higher than that before radiotherapy( P <0.001).Conclusion:pGp expression in NPSC is significantly induced by radiation and radiotherapy increases the overexpression of pGp.Also radiotherapy may be one of the reasons for resistance to chemotherapy after radiotherapy. |
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| Keywords: | Nasopharyngeal carcinoma/Radiotherapy Multi-drug resistance P-glycoprotein Immunhistochemistry |
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