| 市售不同厂家人参多糖注射液的质量评价 |
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| 引用本文： | 万琴,萧伟,王振中,刘莉莉. 市售不同厂家人参多糖注射液的质量评价[J]. 中国中药杂志, 2013, 38(5): 683-686 |
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| 作者姓名： | 万琴 萧伟 王振中 刘莉莉 |
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| 作者单位： | 江苏康缘药业股份有限公司,江苏连云港222001;中药制药过程新技术国家重点实验室,江苏连云港222001 |
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| 基金项目： | 国家"重大新药创制"科技重大专项(2011ZX09401-097) |
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| 摘 要： | 目的:评价目前市面上4个厂家5批次人参多糖注射液的质量.方法:从药物分析的角度,对人参多糖注射液进行常规检查,并测定其相对分子质量和单糖组成.结果:4个厂家的产品均符合相关质量标准和2010年版《中国药典》中的相关规定,但是相对分子质量分布和单糖组成差异很大.结论:建议提高人参多糖注射液的质量标准,保障安全用药.
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| 关 键 词： | 人参多糖注射剂 质量评价 相对分子质量 单糖组成 |
| 收稿时间： | 2012-06-26 |
Quality evaluation of polysaccharide of ginseng injections from different manufacturers |
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| WAN Qin,XIAO Wei,WANG Zhen-zhong and LIU Li-li. Quality evaluation of polysaccharide of ginseng injections from different manufacturers[J]. China Journal of Chinese Materia Medica, 2013, 38(5): 683-686 |
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| Authors: | WAN Qin XIAO Wei WANG Zhen-zhong LIU Li-li |
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| Affiliation: | Jiangsu Kanion Pharmaceutical Co., Ltd, Lianyungang 222001, China;State Key Laboratory of Pharmaceutical Process New-tech for Chinese Medicine, Lianyungang 222001, China;Jiangsu Kanion Pharmaceutical Co., Ltd, Lianyungang 222001, China;State Key Laboratory of Pharmaceutical Process New-tech for Chinese Medicine, Lianyungang 222001, China;Jiangsu Kanion Pharmaceutical Co., Ltd, Lianyungang 222001, China;State Key Laboratory of Pharmaceutical Process New-tech for Chinese Medicine, Lianyungang 222001, China;Jiangsu Kanion Pharmaceutical Co., Ltd, Lianyungang 222001, China;State Key Laboratory of Pharmaceutical Process New-tech for Chinese Medicine, Lianyungang 222001, China |
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| Abstract: | Objective: To evaluate injections of ginseng polysaccharide from 4 different manufacturers of 5 batches on the market. Method: Based on quality analysis, normal examinations were investigated, and monosaccharide composition and the molecular weight of polysaccharide in ginseng injections were performed. Result: Products from 4 different manufacturers were in line with the requirements of quality standard and Chinese Pharmacopeia (2010 edition).But there were great differences in molecular weight and monosaccharide composition. Conclusion: It is suggested to enhance the quality standard to ensure the medication safety use. |
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| Keywords: | polysaccharide of ginseng injection quality evaluation relative molecular weight monosaccharide composition |
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