| 帕米膦酸二钠(博宁)合并化疗缓解多发性骨髓瘤骨痛疗效观察 |
| |
| 引用本文： | 冷芸,陈世伦,石宏志.帕米膦酸二钠(博宁)合并化疗缓解多发性骨髓瘤骨痛疗效观察[J].航天医学与医学工程,2002,15(5):377-378. |
| |
| 作者姓名： | 冷芸 陈世伦 石宏志 |
| |
| 作者单位： | 1. 首都医科大学附属北京朝阳医院血液科,北京,100020
2. 航天医学工程研究所,北京,100094 |
| |
| 摘 要： | 目的评价帕米膦酸二钠 (博宁 )在缓解多发性骨髓瘤患者骨痛中的作用。方法应用博宁联合化疗1 6例与单纯化疗 1 8例进行对照研究。结果博宁联合化疗与单纯化疗均能显著减轻多发性骨髓瘤患者的骨痛程度 (与治疗前比较P <0 .0 1 ) ,博宁联合化疗对骨痛的缓解程度强于单纯化疗 (P <0 .0 5 )。在应用博宁的病例中 ,除 1例出现轻度发热外未见明显毒副作用发生。结论博宁是一种安全有效的双膦酸盐制剂 ,与化疗联合应用可以显著缓解多发性骨髓瘤患者的骨痛。
|
| 关 键 词： | 疗效 多发性骨髓瘤 骨痛 帕米膦酸二钠 博宁 化疗 |
| 文章编号： | 1002-0837(2002)05-0377-02 |
| 修稿时间： | 2002年5月8日 |
Effects of Pamidronate Disodium(Bonin) Combined with Chemotherapy on Bone Pain in Multiple Myeloma |
| |
| LENG Yun,CHEN Shi lun,SHI Hong zhi.Effects of Pamidronate Disodium(Bonin) Combined with Chemotherapy on Bone Pain in Multiple Myeloma[J].Space Medicine & Medical Engineering,2002,15(5):377-378. |
| |
| Authors: | LENG Yun CHEN Shi lun SHI Hong zhi |
| |
| Institution: | Department of Hematology, Chaoyang Hospital, CUMS, Beijing, China. |
| |
| Abstract: | Objective To evaluate the therapeutic effects of Disodium Pamidronate(Bonin) on bone pain in multiple myeloma. Method 18 patients received only chemotherapy and 16 patients with addition of Bonin were compared. Result The bone pain was significantly relieved both in chemotherapy alone group and in the combination group of Bonin with chemotherapy after treatment(P<0.01,as compared with before therapy). However, the effects of combination group were more dramatical than that of the other group(P<0.05).No obvious side effects were observed except mild fever in one patient in the combination group. Conclusion Bonin, as a safe and effective Bisphosphonates preparation, could relieve bone pain in multiple myeloma more effectively when combined with chemotherapy. |
| |
| Keywords: | multiple myeloma bone pain pamidronate disodium (Bonin) chemotherapy |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
