Synthesis and some biological properties of the hexapeptide analog of substance P with a C-terminal thioamide group. |
| |
| Authors: | M Kruszyński G Kupryszewski K Misterek S Gumu?ka |
| |
| Affiliation: | Institute of Chemistry, University of Gdańsk, Poland. |
| |
| Abstract: | A new hexapeptide analog of Substance P, containing a C-terminal thioamide group in the molecule [( Glp6, Mett11]SP6-11) was synthesized: Glp-Phe-Phe-Gly-Leu-Mett-NH2. Conversion to thioamide was accomplished from tert-butoxycarbonyl-L-methionine amide (Boc-Met-NH2) using Lawesson's Reagent. Its contracting activity on isolated guinea-pig ileum was considerably lower than that of [Glp6]SP6-11. |
| |
| Keywords: | |
|
|
