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| 二甲双胍治疗多囊卵巢综合征的临床研究 | |
| 引用本文： | 周海燕,章汉旺,吴集成.二甲双胍治疗多囊卵巢综合征的临床研究[J].中国计划生育学杂志,2004,12(8):483-485. |
| 作者姓名： | 周海燕 章汉旺 吴集成 |
| 作者单位： | 1. 华中科技大学同济医学院在职研究生,湖北省武汉市第一医院妇产科,430022 2. 华中科技大学同济医学院 3. 湖北省武汉市一医院 |
| 摘 要： | 目的:探讨二甲双胍在治疗多囊卵巢综合征的临床效果。方法:30例多囊卵巢综合征(PCOS)患者,口服二甲双胍12周,采取自身对照,观察用药前、后临床症状、血清卵泡刺激素(FSH)、黄体生成激素(LH)、睾酮(T)、雄烯二酮(A2)、空腹血糖及空腹胰岛素水平的变化。结果:继发闭经13例中,7例恢复有排卵月经;月经稀发17例,10例恢复有排卵月经,不孕症16例,用药期间妊娠4例。用药后两组空腹胰岛素和雄激素水平均降低,比较差异有显著性(P<0.05)。结论:二甲双胍可有效改善PCOS患者的胰岛素抵抗状态,降低血中雄激素水平并恢复生育功能。 |
| 关 键 词： | 二甲双胍 多囊卵巢综合征 高胰岛素血症 |
| 修稿时间： | 2004年4月6日 |
Effects of Metformin on Treating Polycystic Ovary Syndrome |
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| Zhou Haiyan,Zhang Hanwang,Wu Jicheng.Effects of Metformin on Treating Polycystic Ovary Syndrome[J].Chinese Journal of Family Planning,2004,12(8):483-485. | |
| Authors: | Zhou Haiyan Zhang Hanwang Wu Jicheng |
| Institution: | Zhou Haiyan,Zhang Hanwang,Wu Jicheng. Department of Obstetrics and Gynecology,the First Hospital,Wuhan 430022 |
| Abstract: | Objective: To investigate the clinical effects of metformin on treating women with polycystic ovary syndrome (P-COS). Methods; 30 of patients took orally metformin for 12 weeks. Clinical symptoms, FSH, LH, T, A2, glucose and insulin were measured before and after taking metformin. Results: Of 13 women with secondary amenorrhea, 7 got back catame-nia. 10 had catamenia again among 17 women with oligomenorrhea. 4 had a pregnancy in 16 of women with infertility. The content of insulin and androgen was less than that before taking medicine, and there was significant difference (P <0. 05). Conclusion: Metformin is effective to reduce the content of insulin and androgen and to recover ovulation in women with PCOS. |
| Keywords: | Metformin Polycystic ovary syndrome Hyperinsulinemia |
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