| Abstract: | The main course of tuberculosis chemotherapy was applied to 85 children at the age of 3 months to 3 years. 62.4, 30.6 and 7.0 per cent of the children suffered from tuberculosis of the intrathoracic lymph nodes, primary tuberculosis and miliary tuberculosis, respectively. The children of younger ages were subjected early during the treatment to intensive chemotherapy consisting of intravenous administration of isoniazid in parallel with 2-3 antituberculous drugs applied to 41.2 per cent of the children and of infusion desintoxication therapy applied to 74.1 per cent of the children. The chemotherapy regimen including isoniazid + streptomycin + ethionamide resulted in clinical recovery 10.1 +/- 0.32 months later, in 48.1 per cent of the patients, the tuberculous inflammation completely resolving, in 40.7 per cent it consolidated and in 11.1 per cent it petrificated. 31 patients with the most severe processes were treated, in addition to the above drugs, with rifampicin as rectal suppositories within 87.0 +/- 3.3 days. The clinical recovery was observed in 10.9 +/- 0.22 months (p greater than 0.05); specific inflammation resolution, consolidation and petrification being observed in 41.9, 45.2 and 12.9 per cent of the children, respectively. The morphofunctional indices of T- and B-immunity markedly lowered at the beginning of the treatment returned to normal 3 months earlier in the patients treated with rifampicin. |
