| 黄芪多糖对去T细胞小鼠促进抗体产生机理的探讨 |
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| 引用本文： | 耿长山,邢善田,周金黄.黄芪多糖对去T细胞小鼠促进抗体产生机理的探讨[J].现代免疫学,1985(2). |
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| 作者姓名： | 耿长山 邢善田 周金黄 |
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| 作者单位： | 军事医学科学院药理毒理研究所，军事医学科学院药理毒理研究所，军事医学科学院药理毒理研究所 |
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| 摘 要： | 黄芪多糖(APS)100mg/kgx6天 ip 可以增加正常小鼠脾脏重量,而对去胸腺与抗胸腺细胞血清处理过的小鼠(T_x-ATS)的作用明显降低。APS 能够显著提高正常小鼠 SRBC 免疫后脾细胞直接溶血空斑(d-PFC)和间接溶血空斑(i-PFC)数量,但对 T_x-ATS 小鼠不能促进d-PFC 数升高。APS 可以提高 T_x-ATS 小鼠在 LPS 免疫后 d-PFC 数,这个作用同 APS 对正常小鼠 SRBC 免疫后的效应相比显著降低。这些结果提示,APS 促进抗体形成作用机理可能是通过 T 细胞介导的。
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STUDIES ON THE MECHANISM OF THE IMMUNOSTIMULATION EFFECT OF ASTRAGALUS POLYSACCHARIDE IN ANTIBODY PRODUCTION IN THYMECTOMIZED MICE |
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| Abstract: | APS,an extract of polysaccharide from Astragalus mongolicus,increased the spleen weight of normal mice at a dosage of 100mg/kg qd.for 6 days.This effect was significantly decreased in thymectomized mice injected with anti-thymus cell serum(T_x-ATS).APS potentiated significantly both the direct and indirect plaque-forming cells(PFC)in normal mice following SRBC immunization,but it did not potentiate direct PFC in T_x-ATS mice. APS could potentiate d-PFC response to LPS immunization in T_x-ATS mice,but this effect was lower than that in normal mice given SRBC.These results suggested that the mechanism of immunostimulatory effect of APS might involve principally an induction of T lymphocyte activity in the body. |
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