法舒地尔治疗肺源性心脏病致心力衰竭的疗效观察

目的观察法舒地尔对肺源性心脏病致心力衰竭患者心脏功能的影响。方法连续入选2009年1月至2010年8月住院的肺源性心脏病心力衰竭患者55例,随机分为法舒地尔组与对照组,连续治疗20 d,观察治疗前后患者血压、心率、左室收缩末期内径(LVESV)、左室舒张末期内径(LVEDV)、左室射血分数(LVEF)、肺动脉收缩压(PASP),6 min步行试验(MwT)、动脉氧分压(PaO2)、二氧化碳分压(PaCO2)及动脉血压含量(SaO2)。结果与对照组相比,治疗组患者PASP明显降低(P0.01),LVESD和LVEDD改善显著(P0.05或P0.01);LVEF和6MwT显著增加(P0.01,);PaO2、SaO2明显增加,PaCO2显著下降(P0.01);收缩压、舒张压及心率无明显变化(P0.05)。结论法舒地尔在治疗肺源性心脏病致心力衰竭有一定疗效,并可以改善左室结构及心功能状态,提高心肌储备。

The efficacy observation on the effect of fasudil to hear failure induced by cor pulmonale

Objective To investigate the efficacy of adding fasudil on top of standard therapy in heat failure induced by cor pulmonale.Methods A total of patients hospitalized in our hospital from Jan 2008 to Sep 2009 were randomly divided into fasudil group and control group and followed 20 days.The changes on left ventricle end-systolic dimension(LVESD),left ventricle end-diastolic dimension(LVEDD),left ventricle ejection fraction(LVEF),pulmonary arterial systolic pressure(PASP) and six-minute walk test(6MwT) were observed;in addition,the level of PaO2,SaO2 and PaCO2 were measured.Results Compared with control group,in fasudil group,dimension of LVESV and LVEDV were markedly decreased;PASP were significantly decreased;LVEF and 6MwT were significantly improved;PaO2,SaO2 increased and PaCO2 decreased;systolic blood pressure(SBP),diastolic blood pressure(DBP) and heart rate(HR) were no significantly changed(P>0.05).Conclusion Fasudil was effective and safe in treating heat failure patients and could significantly improve the cardiac function.