下呼吸道金黄色葡萄球菌的耐药性监测

目的探讨临床下呼吸道感染标本金黄色葡萄球菌(SA)对抗菌药物的耐药状况,为临床合理使用抗菌药物提供参考依据。方法回顾性分析安徽医科大学第一附属医院2006年1月至2010年12月临床各科室送检的合格痰标本,由Mi-croScan WalkWay-Plus全自动微生物分析仪测定。结果大多数抗生素的耐药率有逐渐升高的趋势。其中耐甲氧西林的金黄色葡萄球菌(MRSA)对β-内酰胺类抗生素均耐药,MRSA对各抗生素(除万古霉素和利奈唑胺)的耐药率均高于对甲氧西林敏感的金黄色葡萄球菌(MSSA)。结论 SA为院内感染常见菌,高发病区为外科、呼吸科、耳鼻喉科和肿瘤科,对临床常见抗生素耐药率高且易出现多重耐药,应引起临床高度重视。

Staphylococcus aureus lower respiratory monitoring of drug resistance

Objective To investigate the clinical specimens of lower respiratory tract infections Staphylococcus aureus(SA) on the antimicrobial drug resistance for clinical use of antimicrobial agents provide a reference.Methods Retrospective analysis of the First Affiliated Hospital of Anhui Medical University,January 2006-2010 December submission of the department of qualified clinical sputum samples from MicroScan WalkWay-Plus automatic micro-analyzer.Results The results of most antibiotic resistance rates have gradually increased trend.Including MRSA to β-lactam antibiotics are resistant,MRSA of the antibiotics(except vancomycin and linezolid) were higher than the resistance to MSSA.Conclusion Staphylococcus aureus nosocomial infection of common bacteria,high-incidence area for surgery,respiratory,ENT and oncology,clinical resistance to common antibiotics and is prone to high rate of multi-drug resistance;should lead to clinical attention.