同型半胱氨酸与冠状动脉病变关系的研究

目的探讨血浆同型半胱氨酸(Hcy)与冠状动脉病变支数及年龄的关系.方法对129例病人行冠状动脉造影术及血浆Hcy含量的测定,按冠状动脉造影结果分为冠状动脉正常(CAN)组50例和冠状动脉狭窄(CAS)组87例,其中CAS组进一步分为1支病变组(41例)、2支病变组(10例)和3支病变组(36例).结果 CAS组血浆Hcy含量显著高于CAN组(P<0.01),血浆Hcy含量越高,则冠状动脉病变支数越多,而与年龄无关.结论血浆Hcy含量与冠状动脉病变支数呈正相关,高同型半胱氨酸水平是冠心病的危险因素之一.

Study on the Relationship between Plasma Homocysteine with Coronary Artery Lesion

Objective To investigate the relationship between plasma homocysteine with coronary artery lesion and age.Methods 129 patients underwent coronary angiography. The patients were divided into 2 groups according to their coronary angiography results,87 cases in the coronary artery stenosis (CAS) group and 50 cases in the normal coronary artery (CAN) group. CAS group were divided into single-vessel(n=41),double-vessel(n=10)and triple-vessel(n=36)lesion. Plasma homocysteine(Hcy) was measured before angiography in all subjects.Results Level of plasma Hcy in the CAS group was significantly higher than that in the CAN group.High level of Hcy was associated with increased number of stenosed vessel in CHD patients,and had no relationship with age.Conclusion Level of plasma Hcy has positive correlation with the number of coronary artery with stenosis.High level of plasma Hcy is one of the risk factors for CHD.