广饶县乙肝病毒表面抗原阳性人群及家庭成员随访调查结果

目的了解乙型肝炎（乙肝）表面抗原（HBsAg）阳性人群的转归及家庭成员感染HBV的情况。方法 2009年12月对HBsAg阳性人群（16例）及家庭成员进行HBsAg检测,阳性人员再进行肝功能和血常规（白细胞、血小板）、HBV标志物检测、临床检查以及B超检查,对HBsAg阳性人员进行分类诊断。结果共检测44份血清,其中HBsAg阳性16份（仍为2006年HBsAg阳性者）其余家庭成员HBsAg均阴性。3年内HBsAg阳转阴率为0,仅携带HBsAg者4例（25.0%）,慢性肝炎病人为10例（62.5%）,脂肪肝（轻度）2例,肝硬化为0,无转为肝细胞癌（HCC）者,感染乙肝病毒又感染丙肝病毒的1例。结论 HBsAg阳性者转阴的概率很小,应定期进行查体和继续关注其密切接触者。

Investigation Results on Follow-up of HBsAg-Positive People and their Family Members

Objective]To understand the outcome of HBsAg-positive people and the status of HBV infection among their family members.Methods]HBsAg were tested among HBsAg-positive people（16 cases） and their family members in December 2009.Among people who were detected with HBsA g-positive,liver function,blood routine examination（including leukocyte and blood platelet）,HBV marker detection,clinical examination and B ultrasonic examination were performed.The classification diagnosis adopted among HBsAg-positive people.Results]Among 44 serum samples which were tested,16 were HBsAg-positive（all of them were HBsAg-positive people in 2006）,the family members were all negative.The negative conversion rate was 0 in three years.There were 4（25%） cases of HbsAg carrier,10（62.5%） cases of chronic hepatitis,2 cases of fat liver（light）,no hepatic cirrhosis and hepatocellular carcinoma（HCC） case.One case was infected with HBV and HCV.Conclusion]The negative conversion rate of HBsAg-positive people is very little.It is necessary to carry out the regular physical examination and pay attention to the close contacts.