氟尿嘧啶联合丝裂霉素胸腔注射治疗高龄恶性胸腔积液

目的探讨氟尿嘧啶(5-Fu)联合丝裂霉素(MMC)胸腔注射治疗高龄恶性胸腔积液的疗效.方法病理确诊的肺癌伴恶性胸腔积液高龄患者37例,随机分为治疗组(20例)和对照组(17例).治疗组胸腔内注射5-Fu 750 mg/m2,MMC 8 mg/m2;对照组胸腔内注射顺铂(DDP)40 mg/m2,每3～5天一次,共3～5次.观察疗效、毒副反应及生活质量.结果治疗组总有效率为75.0%,对照组为70.6%,差异无显著性(P>0.05).治疗组骨髓抑制、胃肠反应明显低于对照组(P<0.05).治疗组Karnofsky评分>60分者较对照组显著提高(P<0.05),<50分者较对照组明显下降(P<0.05).结论 5-Fu联合MMC胸腔注射治疗老年恶性胸腔积液是一种安全性高、毒副反应小、耐受性好的有效方法.

Treatment of malignant pleural effusion using 5-Fu and MMC injection into pleural cavity in the elderly

Objective To evaluate the efficacy of 5-fluorouracil (5-Fu) and mitomycin (MMV) injection into pleural cavity in treating malignant pleural effusion.Methods Thirty-seven old patients with malignant pleural effusion were divided randomly into 2 groups.5-Fu 750 mg/m2 and MMC 8 mg/m2 were injected into pleural cavity in therapy group(T),and only cisplatin (DDP) 40 mg/m2 was given in control group (C).The injection was given once 3 to 5 days for 3 to 5 times successively.Then the efficacy,toxicity and quality of life were evaluated.Results The response rate was 75.0% in T group and 70.6% in C group.There was no statistical difference betwee two groups (P>0.05),The Karnofsky score was higher in T group than in C group(P<0.05).Myelosuppession,nausea and vomiting were significantly lower in T group than in C group (P<0.05).Conclusion The treatment with 5-Fu and MMC is a safe,and well tolerable method with little side effects for treating malignant pleural effusion in the elderly.