氯吡格雷联合阿托伐他汀治疗老年不稳定性心绞痛疗效观察

目的：探讨氯吡格雷联合阿托伐他汀治疗老年不稳定性心绞痛患者的临床疗效及安全性。方法：将109例不稳定性心绞痛患者随机分为治疗组54例和对照组55例,两组均给予硝酸酯类药物、β受体阻滞剂等治疗。治疗组加氯吡格雷75 mg,每日1次口服;阿托伐他汀20 mg,睡前口服,疗程为12周。比较两组患者治疗后心绞痛症状控制情况及血脂情况。结果：治疗组总有效率为92.59%;对照组总有效率为70.90%,两组疗效比较差异有统计学意义（P〈0.05）;治疗组治疗后血清三酰甘油、总胆固醇和低密度脂蛋白显著低于对照组（P〈0.05）;两组均无出血等不良反应。结论：氯吡格雷联合阿托伐他汀治疗不稳定性心绞痛临床效果较好,安全,值得临床推广使用。

Clinical observation of Clopidogrel combined with Atorvastatin on senile unstable angina

Objective： To discuss the efficacy and safety of Clopidogrel combined with Atorvastatin on senile unstable angina.Methods： 109 patients with unstable angina were randomly divided into treatment group（54 cases） and control group（55 cases）.Two groups were both given nitrates,β blockers and other treatment.Treatment group was given Clopidogrel oral dose of 75 mg per day and Atorvastatin 20 mg orally at bedtime daily for 12 weeks,and comparatively analyze the data of two groups.The situations of angina symptom controls and blood lipids after treatment were compared.Results： The total effective rate of treatment group was 92.59% while control group was 70.90%;the difference between two groups was statistically significant（P0.05）.After treatment,serum triglycerides,total cholesterol and LDL of treatment group were significantly lower than the control group（P0.05）.There was no bleeding and other adverse reactions in two groups.Conclusion： The clinical effect of Clopidogrel combined with Atorvastatin on unstable angina is better and safe,and it is worthy of clinical application.