| 七氟烷后处理对大鼠在体心肌抗氧化的影响 |
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| 引用本文： | 李婧,韩冲芳,李晓欣,杜艺,杨文曲.七氟烷后处理对大鼠在体心肌抗氧化的影响[J].中国医药导报,2011,8(20):15-16. |
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| 作者姓名： | 李婧 韩冲芳 李晓欣 杜艺 杨文曲 |
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| 作者单位： | 山西医科大学第一医院麻醉科,山西太原,030001 |
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| 摘 要： | 目的：探讨七氟烷后处理对大鼠在体心肌抗氧化的作用及最佳浓度。方法：将40只健康雄性SD大鼠分为5组,即假手术组（C组）、缺血再灌注组（IP组）、1%、2%、3%七氟烷后处理组（S1、S2、S3组）,每组各8只,建立大鼠在体心肌缺血再灌注模型。测定再灌注3 h后血浆MDA、SOD和CK-MB含量和心肌梗死面积。结果：与IP组相比,各S组心肌梗死面积、MDA、CK-MB均显著降低（P〈0.05）,SOD含量均显著升高（P〈0.05）。S1组与S3组各指标间比较,差异无统计学意义（P〉0.05）。与S1、S3组相比,S2组心肌梗死面积（28.5±1.35）%、MDA（8.205±2.874）nmol/ml、CK-MB（22.935±2.064）U/L均显著降低（P〈0.05）,SOD含量显著升高（P〈0.05）。结论：七氟烷后处理可通过调节MDA与SOD的表达,发挥心肌保护作用,且中剂量组（2%七氟烷）效果更明显。
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| 关 键 词： | 七氟烷后处理 心肌缺血再灌注 抗氧化 |
The effect of sevoflurane postconditioning on antioxidation of rat hearts in vivo |
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| LI Jing,HAN Chongfang,LI Xiaoxin,DU Yi,YANG Wenqu.The effect of sevoflurane postconditioning on antioxidation of rat hearts in vivo[J].China Medical Herald,2011,8(20):15-16. |
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| Authors: | LI Jing HAN Chongfang LI Xiaoxin DU Yi YANG Wenqu |
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| Institution: | LI Jing,HAN Chongfang,LI Xiaoxin,DU Yi,YANG Wenqu Department of Anesthesiology,the First Affiliated Hospital of Shanxi Medical University,Shanxi Province,Taiyuan 030001,China |
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| Abstract: | Objective:To investigate the antioxidation of sevoflurane postconditioning in rat hearts in vivo and the best concentration.Methods:A total of 40 SD rats were randomly divided into 5 groups,sham operation group(group C),ischemia and reperfusion group(group IP),1%,2%,3% sevoflurane postconditioning group(group S1,group S2,group S3),8 in every group,the model of rats' myocardial ischemia reperfusion was established.After being reperfused for 3 h,the blood SOD,MDA,CK-MB and myocardial infarct size were measure... |
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| Keywords: | Sevoflurane postconditioning Myocardial ischemia reperfusion Antioxidation |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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