阿托伐他汀对急性心肌梗死患者心律失常的影响

目的：探讨阿托伐他汀治疗急性心肌梗死（AMI）患者心律失常的临床疗效。方法：将我院2009年1月～2011年2月收治的90例AMI心律失常患者随机分为对照组与观察组,每组45例。对照组在常规治疗基础上给予烟酸缓释片;观察组在常规治疗基础上给予阿托伐他汀治疗。两组均连续治疗6个月,观察两组患者的室性心律失常、房颤、心力衰竭、再发心绞痛、心肌梗死以及猝死发生率;检测两组患者治疗前后血胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、三酰甘油（TG）以及脂蛋白a（Lpa）的变化。结果：观察组室性心律失常（8.9%）、房颤（6.7%）、心力衰竭（15.6%）、心肌梗死复发（4.4%）以及猝死率（2.2%）均明显低于对照组（26.7%、28.9%、33.0%、17.7%、8.9%）（P〈0.05）;治疗后观察组血脂水平TC（3.42±0.85）mmol/L、LDL-C（1.72±0.53）mmol/L、TG（1.40±0.27）mmol/L、Lpa（146.0±72.6）mg/L]均明显低于对照组（5.87±1.21）mmol/L、（3.64±0.96）mmol/L、（3.68±0.95）mmol/L、（288.5±92.1）mg/L]（P〈0.05）。结论：阿托伐他汀治疗AMI心律失常的临床疗效确切,值得推广应用。

Influence of Atorvastatin to arrhythmia in acute myocardial infarction patients

Objective： To study clinical efficacy of Atorvastatin in treatment of acute myocardial infarction（AMI） patients with arrhythmia.Methods： 90 cases of AMI patients with arrhythmia in our hospital from January 2009 to February 2011 were randomly divided into control group and observation group,45 patients in each group.The control group was given Enduraic on base of routine treatment;observation group was given Atorvastatin treatment.Both groups were treated continuously for 6 months,to observe ventricular arrhythmia,atrial fibrillation,heart failure,recurrent angina pectoris and myocardial infarction and sudden death rate of all patients;and detect changes of blood cholesterol（TC）,low-density lipoprotein cholesterol（LDL-C）,triglycerides（TG） and lipoprotein a（Lpa） before and after treatment.Results： The ventricular arrhythmias（8.9%）,atrial fibrillation（6.7%）,heart failure（15.6%）,recurrent myocardial infarction（4.4%） and death（2.2%） of observation group were significantly lower than control group（26.7%,28.9%,33.0%,17.7%,8.9%）（P0.05）;lipid levels of observation group TC（3.42±0.85） mmol/L,LDL-C（1.72±0.53） mmol/L,TG（1.40±0.27） mmol/L,Lpa（146.0±72.6） mg/L] were significantly lower than the control group （5.87±1.21） mmol/L,（3.64±0.96） mmol/L,（3.68±0.95） mmol/L,（288.5±92.1） mg/L]（P0.05）.Conclusion： Clinical efficacy of Atorvastatin in treatment of arrhythmia in AMI is good,and should be widely applied.