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| 电针肝俞、期门对肝气郁结模型大鼠行为学及HPA轴相关激素的影响 | |
| 引用本文： | 刘子旺,赵海滨,张秀静,单保慈,刘华,贺立娟.电针肝俞、期门对肝气郁结模型大鼠行为学及HPA轴相关激素的影响[J].针灸临床杂志,2011,27(12):46-48. |
| 作者姓名： | 刘子旺 赵海滨 张秀静 单保慈 刘华 贺立娟 |
| 作者单位： | 1. 北京中医药大学第三附属医院,北京,100029 2. 中国科学院高能物理研究所,北京,100039 3. 北京中医药大学东方医院,北京,100078 |
| 基金项目： | 高等学校博士学科点专项科研基金，首都医学发展科研基金 |
| 摘 要： | 目的:探讨电针对肝气郁结模型大鼠行为学影响及下丘脑-垂体-肾上腺(HPA)轴相关激素的调节作用。方法:将Wistar大鼠30只随机分为正常对照组、肝郁模型组、电针治疗组,通过开野实验(Open-Field Test)及蔗糖水消耗实验进行大鼠行为学检测,运用ELISA法检测大鼠血清促肾上腺皮质激素释放激素(CRH)、皮质酮(CORT)含量,3组之间进行比较。结果:与正常组相比,模型组Open-Field Test水平运动得分和垂直运动得分明显减少,蔗糖水偏嗜度明显减少,血清CORT、CRH的含量明显升高,而电针明显增加模型大鼠的水平得分、垂直得分及蔗糖水偏嗜度,并可阻抑血清CRH、CORT的过度分泌。结论:肝气郁结大鼠存在活动度降低、探究行为减少、快感缺失和HPA轴亢进,电针肝俞、期门可抑制CRH、CORT的过度分泌,缓解HPA轴亢进,外在体现为对模型大鼠行为学的改善。 |
| 关 键 词： | 电针 肝气郁结 HPA轴 行为学 促肾上腺皮质激素释放激素 皮质酮 |
Effect of Electroacupuncture at Gan Shu, Qi Men on Changes of Behaviors and Related Hormones of Hypothalamus - Pituitary - Adrenal Axis in Rats with Syndrome of Stagnation of Liver - Qi |
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| LIU Zi-wang,ZHAO Hai-bin,ZHANG Xiu-jing,SHAN Bao-ci,LIU Hua,Li-juan.Effect of Electroacupuncture at Gan Shu, Qi Men on Changes of Behaviors and Related Hormones of Hypothalamus - Pituitary - Adrenal Axis in Rats with Syndrome of Stagnation of Liver - Qi[J].Journal of Clinical Acupuncture and Moxibustion,2011,27(12):46-48. | |
| Authors: | LIU Zi-wang ZHAO Hai-bin ZHANG Xiu-jing SHAN Bao-ci LIU Hua Li-juan |
| Institution: | LIU Zi-wang1,ZHAO Hai-bin1,ZHANG Xiu-jing1,SHAN Bao-ci2,LIU Hua2,HE Li-juan3(1.The Third Affiliated Hospital of Beijing University of Traditional Chinese Medicine,Beijing 100029,China,2.Institute of High-energy Physics,Chinese Academe of Sciences,Beijing 100039,3.Dongfang Hospital,Beijing 100078,China) |
| Abstract: | Objective:To investigate the effect of electroacupuncture(EA) on changes of behaviors and some related hormones of the hypothalamus-pituitary-adrenal(HPA) axis in rats with stagnation of liver-qi syndrome. Methods:The rats were randomly divided into three groups: normal group,model group,EA group,n=10.We judged the behavioral changes of model rats and the behavioral action of EA in treating the stagnation of liver-qi syndrome through Open-Field Test and partial addicted to sugar water test.The content of ad... |
| Keywords: | Electroacupuncture Stagnation of Liver-Qi syndrome HPA axis Behavior CRH CORT |
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