| 不同剂量照射对胸腺细胞四个亚组的影响 |
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| 引用本文： | 苏旭,张迎春,刘树铮.不同剂量照射对胸腺细胞四个亚组的影响[J].中华放射医学与防护杂志,1995,15(2):103-105. |
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| 作者姓名： | 苏旭 张迎春 刘树铮 |
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| 作者单位： | 130021 长春, 白求恩医科大学卫生部放射生物实验室;130021 长春, 白求恩医科大学卫生部放射生物实验室;130021 长春, 白求恩医科大学卫生部放射生物实验室 |
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| 摘 要： | 本实验采用双荧光流式细胞术研究了不同剂量x射线照射后24小时,昆明小鼠胸腺T细胞四个亚组的变化,结果表明：各亚组对辐射的敏感性有较大的差异。其辐射敏感性依次为CD4+CD8+CD4-CD8-CD4-CD8+CD4+CD8-,由于各亚组辐射敏感性的差异,导致了大剂量照射后各亚组之间比例的改变。
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| 关 键 词： | 电离辐射 胸腺细胞亚组 流式细胞术 |
| 收稿时间： | 1994/4/27 0:00:00 |
| 修稿时间： | 1994/7/19 0:00:00 |
Effects on subsets of thymic lymphocytes after X-irradiation with different doses |
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| Su Xu,Zhang Yingchun and Liu Shuzheng.Effects on subsets of thymic lymphocytes after X-irradiation with different doses[J].Chinese Journal of Radiological Medicine and Protection,1995,15(2):103-105. |
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| Authors: | Su Xu Zhang Yingchun and Liu Shuzheng |
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| Institution: | MH Radiobiology Research Unit.Norman Bethune University of Medical Sciences, Changchun, 130021;MH Radiobiology Research Unit.Norman Bethune University of Medical Sciences, Changchun, 130021;MH Radiobiology Research Unit.Norman Bethune University of Medical Sciences, Changchun, 130021 |
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| Abstract: | Kunming Mice were whole-body irradiated with 0.5,1.0,2.0and 4.0 Gy X-rays.The thymic lymphocytes were analyzed by flow cytometry with fluorecscent monoclonal antibodies 24 hours after irradiation.It was found that the percentages of CD4+CD8-,GD4-CD8+ and CD4-CD8- cells increased in varying degrees,while the percentage of CD4+CD8+ cells showed a dose -dependent decrease.However,the absolute number of total thymic lymphocytes and the subsets decreased.The absolute number of CD4+CD8+ cells decreased more markedly than that of other subsets.These observations suggest that the radiosensitivity varied in different stages of differentiations of.the thymocytes.The order of radiosensitivity was:CD4+CD8+>CD4-CD8->CD4-CD8+> CD4+CD8-. |
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| Keywords: | Gamma radiation T subsets flow cytometry |
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