CB微核法在忻州事故生物剂量估算中的应用

本文作者报道了在忻州放射事故中３４例受检者ＣＢ法微核的检测结果。同时，用本实验室建立的ＣＢ微核剂量效应曲线对上述受检者进行生物剂量估算，并与染色体畸变分析估算的剂量进行比较，结果两种方法估算的剂量基本一致。表明ＣＢ微核法是估算事故受照者所受剂量的一种较为理想的方法。

Application of cytokinesis-block micronuleus method in radiation accident in Xinzhou City of Shanxi Province

This paper reports a radiation accident on November 19,1992in Xinzhou City of Shanxi Province,China.A woman patient,aged 24,with undetermined history of radiation exposure, was proved to have been exposed to high dose irradiation in the light of chromosome aberrations in peripheral lymphocytes.The absorbed dose estimated based on the frequency of dicentrics plus rings was equivalent to 2.30 Gy of homogeneous whole body irradiation with the 95% confidence limit of 2.07-2.50 Gy. With this diagnosis,the following advice was offered:(1)immediate search for the radiation source with a view to eradicating as soon as possible the menace to the safety and health of local inhabitants;(2) medical surveillance of potentially irradiated people. estimation of exposure dose,and taking proper measures;and(3) appropriate treatment of the patient.After energetic effort,an abandoned sealed 60Co source was at last found.At the 38-70th days after the accident,the frequencies of chromosome aberrations and micronuclei were examined by cytokinesis-block micronucleus method for 34 individuals.Exposure doses were estimated by using the cytogenetic technique.The results of micronucleus and dicentric plus ring assays were similar,so that CB micronucleus method can be used for estimating exposure dose to individuals.