| 低剂量照射对LAK细胞体外杀伤肿瘤靶细胞的影响 |
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| 引用本文： | 傅强,张澜生,朱寿彭,刘新垣.低剂量照射对LAK细胞体外杀伤肿瘤靶细胞的影响[J].中华放射医学与防护杂志,1995,15(5):321-325. |
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| 作者姓名： | 傅强 张澜生 朱寿彭 刘新垣 |
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| 作者单位： | 苏州医学院细胞免疫研究中心，苏州医学院放射医学系，中国科学院上海生物化学研究所 |
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| 摘 要： | 作者采用＾Ｈ－ＴｄＲ释放实验，观察了低剂量γ射线照射的ＬＡＫ细胞体外杀伤肿瘤靶细胞的影响。来自健康献血员的外周血淋巴细胞，用重组白介素２培养９６小时获取ＬＡＫ效应细胞，在细胞培养的不同时期给予培养中的细胞一次不同剂量的γ射线照射。
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| 关 键 词： | 低剂量照射 LAK细胞 细胞毒活性 |
| 收稿时间： | 1/3/1995 12:00:00 AM |
| 修稿时间： | 4/4/1995 12:00:00 AM |
Effect of low dose gamma-ray irradiation on cytotoxicity of LAK cells against target tumor cells |
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| Fu Qiang,Zhang Lansheng,Zhu Shoupeng.Effect of low dose gamma-ray irradiation on cytotoxicity of LAK cells against target tumor cells[J].Chinese Journal of Radiological Medicine and Protection,1995,15(5):321-325. |
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| Authors: | Fu Qiang Zhang Lansheng Zhu Shoupeng |
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| Institution: | Centre of Cellular Immunology, Suzhou Medical College, Suzhou, 215007;Centre of Cellular Immunology, Suzhou Medical College, Suzhou, 215007 |
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| Abstract: | Using a 3H-TdR release assay,the effect of low dose gammaray irradiation on cytotoxicity of LAK cells against target tumor cells in vitro was observed.Peripheral blood lymphocytes from healthy blood donors were cultured with rIL-2 for 96h to obtain LAK effector cells. LAK cells with different culture times(24, 48, 72h)were exposed to various single dose gamma-ray irradiation (0.66, 1.31, 2.62, 5.24mGy) .This experiment demonstrated that low dose gamma-ray irradiation was able to enhance cytotoxic activity of LAK cells, and the most obvious enhancement of cytotoxicity was noted in the 72h experimental group.There were statistically significant differences between the experimental groups and the control group. The results suggest that there possibly exist hormetic effects of low dose irradiation on LAK cell cytotoxicity. |
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| Keywords: | Low dose gamma irradiation LAK cells cytotoxicity |
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