Primary gastric Ki-1 positive anaplastic large cell lymphoma: A report of two cases |
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| Authors: | Naoyoshi Mori Yasushi Yatabe Kuniyuki Oka Tomoyuki Yokose Tatsuya Ishido Masanori Kikuchi Junpei Asai |
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| Affiliation: | First Department of Pathology, Nagoya University, School of Medicine, Nagoya;Section of Hospital Laboratory Hospital, National Institute of Radiological Sciences, Chiba;Division of Clinical Pathology and Internal Medicine, Tokyo Metropolitan Tama Geriatric Hospital, Tokyo;Internal Medicine, National Cancer Center Hospital, Tokyo;Department of Pathology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan |
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| Abstract: | Two cases with primary gastric Ki-1 positive anaplastic large cell lymphoma are presented. Morphologic features of both cases involved pleomorphism of the neoplastic cells, fibrosis and lymphatic infiltration. The neoplastic cells in both cases were positive for BerH2 (CD30), LCA(CD45), lysozyme and alpha-1-antitrypsin (α1-AT). In additional case, the neoplastic cells were additionally positive for MAC387 and (α1,-antichymotrypsin (α,-ACT). The neoplastic cells in these cases were negative for L26(CD20), UCHL-1 (CD45RO), DAKO CD3 and epithelial membrane antigen (EMA). According to the results of the phenotypic studies, the authors consider that the neoplastic cells have some of the features of histiocytes.
Both patients at 2 and 8 years after surgery without chemotherapy are disease free. This lymphoma is well known to be frequently misdiagnosed as undifferentiated carcinoma. Although rare in occurrence, recognition of this primary lymphoma in the stomach has a significant clinical implication, as the authors consider that its prognosis might be better than undifferentiated carcinoma of the stomach. |
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| Keywords: | anaplastic large cell lymphoma histiocytic lymphoma Ki-1 antigen primary gastric lymphoma |
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