裸花紫珠片联合贝那普利治疗IgA肾病的临床疗效观察

目的观察裸花紫珠片联合贝那普利治疗原发性IgA肾病的临床疗效。方法经过肾活检确诊的原发性IgA肾病62例，按数字表法随机分为对照组和观察组，每组31例。2组患者均给予常规治疗，包括饮食治疗（低盐低脂、低磷、优质蛋白质饮食）、充分休息、避免劳累及感冒。对照组在常规治疗的基础上，加用贝那普利10mg，每日1次，使血压维持在125／75mmHg以内；观察组在对照组基础上加用裸花紫珠片1．0g，每日3次；2组疗程均为3个月。检测2组治疗前、后血浆纤维蛋白原（fibringen，FIB）、血肌酐（SCr）、肌酐清除率（Ccr）、24h尿蛋白定量等变化情况及不良反应。结果观察组与对照组相比，观察组在降低FIB、SCr水平，提高Ccr水平等方面均优于对照组，差异有统计学意义（P〈0．05）。治疗后2组患者24h尿蛋白定量组问比较无统计学差异（P〉O．05）。未发现皮疹、肝功能损害等其他明显不良反应。结论应用裸花紫珠片和贝那普利联合治疗原发性IgA肾病的临床疗效优于单用贝那普利，对IgA肾病有一定的治疗价值。

Effect observation of callicarpa nudiflora combined with benazepril in IgA nephropathy

Objective To observe the curative effect of Callicarpa Nudiflora combined with Benazepril in IgA nephropathy. Methods with Retrospective analysis, 62 patients with primary IgA nephropathy through renal biopsy were randomly divided into treatment group and control group, with conventional treatment for 3 months, the patients in the control group were given Benazepril, and the patient in the treatment group were given Benazepril and Callicarpa Nudiflora. Then, fibrinogen （FIB）, serum creatinine（SCr）,and 24 hour urinary protein quantitative, as well as adverse reactions, would be recorded respectively. Results in consideration of reducing FIB SCr, and improving Ccr lev- el, Callicarpa Nudiflora combined with Benazepril （treatment group） was better than Benazepril （con- trol group） for primary IgA nephropathy （P〈0. 05）. After 2 months treatment, the difference of 24 hour urinary protein quantitative between 2 groups had no statistical significance. And The treatment group didn＇t been found rash, liver damage and other adverse reactions, having better function of renal protection than control group. Conclusions clinical curative effect of the combined application of Calli- earpa Nudiflora and Benazepril for primary IgA nephropathy was better than that of using Benazepril only, with significantly therapeutic value for IgA nephropathy.