Interferon-gamma as an adjuvant in immunocompromised mice. |
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| Authors: | A W Heath M E Devey I N Brown C E Richards J H Playfair |
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| Affiliation: | Department of Immunology, U.C.S.M., London, U.K. |
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| Abstract: | We have compared interferon-gamma (IFN-gamma) with saponin and interleukin-1 (IL-1) as adjuvants for a blood-stage malaria vaccine in mice with various immunological abnormalities. IFN-gamma was particularly effective in Biozzi low antibody responder mice, mice selectively bred to produce antibody of low affinity, and mice depleted of CD4+ T cells. IFN-gamma and other cytokines may be safe adjuvants for use in human immunodeficiency states. |
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