丙酸氟替卡松联合万托林对婴幼儿反复喘息的疗效观察

目的通过对反复喘息的患儿采用丙酸氟替卡松（flixotide FP）联合万托林配合储雾罐吸入治疗，观察该方法在急性期控制症状和病后一年内喘息发生的情况。方法60例患儿随机分为两组，治疗组用FP及万托林配合储雾罐，每天两次；在急性喘息好转后继续吸入辅舒酮12周，每天一次，当出现咳嗽、流鼻涕等感冒症状时，再加万托林吸入，每天两次，持续5～7d，感冒症状消失即停止吸入；疗程结束后，每当出现感冒症状时就两药同时加上，每天两次，大约3～5d感冒症状消失后，同时停止吸入。对照组仅予常规综合治疗。结果两组患儿急性期在喘憋、肺部哮鸣音、咳嗽消失方面差异有统计学意义（P〈0．01），且病后一年内喘息发生次数与喘息持续的时间，治疗组明显优于对照组（P〈0．05）。结论吸入FP及万托林对婴幼儿反复喘息的临床疗效确切，缓解喘息症状迅速，短期吸入可降低喘息再发的次数，可作为预防反复喘息的干预措施。

Effect of on recurrent wheezing in infants fluticasone propionate combined ventolin

Aim To observe the effect of treating children recurrent wheezing with fluticasone propionate(FP) and ventolin inhalation.Methods 60 children cases were randomly divided into two groups:the therapeutic group(34 cases)received flixotide inhalation twice a day,inhaling flixotide once a day for 12 weeks when the acute wheezing was improved.When coughing,runny nose and other cold symptoms,it was coupled with ventolin inhalation twice a day for 5～7 days;After 12-week treatment,two drugs were used twice a day for 3～5 days before stop.The control group(26 cases)received nothing.Results Asthmatic,wheezing sound,cough disappeared in acute phase.There was significant difference between the two groups(P<0.05).In frequency and duration of wheezing,the treatment group was remarkably better than the control within one year after suffering from this disease(P<0.05).Conclusion Inhaling FP and ventolin can improve clinical efficacy and rapidly alleviate the symptoms,and short-term inhaling can reduce the frequency of recurrent wheezing.As a preventive intervention,it’s safe and worth promoting.