同型半胱氨酸水平与复发脑梗死关系的临床研究

目的探讨同型半胱氨酸水平与复发性脑梗死的关系,评价同型半胱氨酸在脑梗死复发中的作用和意义。方法 520例急性脑梗死患者均测定同型半胱氨酸水平,根据同型半胱氨酸水平分为高hcy组（Hhcy组）与正常hcy组（Nhcy组）,追踪观察2年,统计其复发率,并对复发脑梗死患者根据其梗死病灶大小分组并统计其同型半胱氨酸水平的差异。结果 Hhcy组脑梗死复发率（16.9%）显著高于Nhcy组（8.9%）,hcy水平越高复发脑梗死的梗死灶越大。结论同型半胱氨酸水平增高,脑梗死复发的风险增加,梗死灶增大。

Clinical Study on the Relationship between the Level of Homocysteine and Recurrent Cerebral Infarction

Objective To investigate the relationship between homocysteine（hcy） level and recurrent cerebral infarction and evaluate its effects and significance concerning in the occurrence of cerebral infarction.Methods Five hundred and twenty patients with acute cerebral infarction were assayed plasma hcy level and were divided into a hyper hcy group（Hhcy group） and a normal hcy group（Nhcy group） according to the level of plasma homocysteine.The recurrence rate of cerebral infarction of both groups was calculated during the following 2 years.And evaluate the difference among plasma hcy level of recurrent cerebral infarction patients who were divided into three groups due to the infarcted brain area.Results The recurrent rate of the Hhcy group was 16.9% and significantly higher than that of the Nhcy group（P0.05）,which was 8.9%.The higher the plasma hcy level was,the bigger the infarcted brain area in recurrent cerebral infarction was.Conclusion The elevated plasma homocysteine level can increase the possibility of recurrentce after previous cerebral infarction and increase the infarcted brain area.