| 大鼠急性肝功衰竭模型的建立及肝再生刺激因子的救治 |
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| 引用本文： | 姚志强,杨为松,陈勇,张文彬,杨凤仪.大鼠急性肝功衰竭模型的建立及肝再生刺激因子的救治[J].第四军医大学学报,1991(2). |
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| 作者姓名： | 姚志强 杨为松 陈勇 张文彬 杨凤仪 |
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| 作者单位： | 唐都医院传染科
(姚志强，杨为松，陈勇，张文彬)，唐都医院传染科(杨凤仪) |
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| 摘 要： | 作者采用D畔乳糖胺(D-GL)制备大鼠急性肝衰竭(FHF)模型,并观察了肝再生刺激因子(HSS)对大鼠FHF的救治效果.结果表明:D-GL诱发Wistar大鼠FHF的最适剂量为1.6g/kg;大鼠中毒后20h经腹腔注射HSS(总蛋白量为26mg)或生理盐水4ml,治疗组(n=12)大鼠2周存活率为33.3％,与对照组(0,n=12)相差显著(P<0.05)。提示人胎HSS可有效地提高FHF大鼠的存活率,有希望成为一种新的治疗FHF的有效药物。
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| 关 键 词： | 肝衰竭 疾病模型 动物 肝再生 生长因子 D—半乳糖胺 |
Effect of hepatic stimulator substance from human fetal liver on D-galactosamine induced acute hepatic failure in rats |
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| YAO Zhi Qiang,YANG Wei Song,CHEN Yang,ZHANG Wen Bin and YANG Feng - Yi.Effect of hepatic stimulator substance from human fetal liver on D-galactosamine induced acute hepatic failure in rats[J].Journal of the Fourth Military Medical University,1991(2). |
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| Authors: | YAO Zhi Qiang YANG Wei Song CHEN Yang ZHANG Wen Bin and YANG Feng - Yi |
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| Institution: | YAO Zhi Qiang,YANG Wei Song,CHEN Yang,ZHANG Wen Bin and YANG Feng - YiDepartment of Infectious Diseases,Tangdu Hospital |
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| Abstract: | A liver specific growth factor - hepatic stimulator substance (HSS) was partially purified from human fetal liver cells and the effect of HSS in reversing the lethality of D-galactosamine (1.6 g/kg body weight) induced hepatic necrosis in rats was evaluated 20 h after poisoning , the rats were treated with HSS 4 ml or saline and the survival rate of rats in each group was examined for 2 weeks. A significantly improved survival rate of 33.3% in HSS group (n = 12) was observed compared with saline control (n = 12, 0.0%; P<0.05). The result suggests that HSS can successfully improve the survival rate in rats with D-galactosaminc induced acute liver failure and may represent a significant potential for the management of acute hepatic failure. |
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| Keywords: | hepatk failure disease models animal liver regeneration growth factor D-galactosamine |
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